An overview of the methods used to increase the dissolution rate of meloxicam for oral administration

B Jadach, A Froelich, A Tatarek, T Osmałek - Journal of Drug Delivery …, 2024 - Elsevier
Oral administration of a drug substance has become one of the most important drug delivery
routes. In chronic diseases such as rheumatoid arthritis or osteoarthritis, oral forms of drugs …

The role of pH and dose/solubility ratio on cocrystal dissolution, drug supersaturation and precipitation

TC Machado, G Kuminek, SG Cardoso… - European Journal of …, 2020 - Elsevier
Cocrystals that are more soluble than the constituent drug, generate supersaturation levels
during dissolution and are predisposed to conversion to the less soluble drug. Drug release …

Pharmaceutical salts of piroxicam and meloxicam with organic counterions

S Huang, DS Venables, SE Lawrence - Crystal growth & design, 2022 - ACS Publications
Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs,
belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six …

Eutexia for enhanced dissolution rate and anti-inflammatory activity of nonsteroidal anti-inflammatory agents: Caffeine as a melting point modulator

RA Alshaikh, EA Essa, GM El Maghraby - International journal of …, 2019 - Elsevier
Fast dissolution of nonsteroidal anti-inflammatory drugs (NSAIDs) is a prerequisite from
patient perspective. However, most NSAIDs are slowly dissolving acidic compounds …

Dissolution and permeability properties of co-amorphous formulations of hydrochlorothiazide

M Ruponen, H Rusanen, R Laitinen - Journal of Pharmaceutical Sciences, 2020 - Elsevier
A biopharmaceutics classification system class IV drug, hydrochlorothiazide (HCT), was
combined with co-formers of L-and d-arginine (ARG) and sodium lauryl sulphate (SLS) by …

Permeability of glibenclamide through a PAMPA membrane: The effect of co-amorphization

M Ruponen, M Visti, R Ojarinta, R Laitinen - European Journal of …, 2018 - Elsevier
Co-amorphous systems are an attractive alternative for amorphous solid polymer
dispersions in the formulation of poorly soluble drugs. Several studies have revealed that co …

Development of a fast dissolving sublingual film containing meloxicam nanocrystals for enhanced dissolution and earlier absorption

Q Song, C Shen, B Shen, W Lian, X Liu, B Dai… - Journal of Drug Delivery …, 2018 - Elsevier
The objective of this work was to prepare and evaluate fast dissolving sublingual films
containing meloxicam nanocrystals (MLX-NS-FDSFs). Nanocrystals (NS) were utilized to …

New Drug Delivery Systems for Stable Oral Absorption: Theory, Strategies, and Applications

S Onoue - Biological and Pharmaceutical Bulletin, 2024 - jstage.jst.go.jp
The oral dosage route still remains the most common and preferred route for drug
administration due to convenient handling, high patient compliance, and cost-effectiveness …

Amorphous solid dispersion of meloxicam enhanced oral absorption in rats with impaired gastric motility

H Suzuki, K Yakushiji, S Matsunaga… - Journal of …, 2018 - Elsevier
Meloxicam (MEL) shows a slow onset of action in severe pain patients on account of
delayed gastric motility. This study aimed to develop an amorphous solid dispersion (ASD) …

Multiparticulate systems of meloxicam for colonic administration in cancer or autoimmune diseases

E Navarro-Ruíz, C Álvarez-Álvarez, MÁ Peña… - Pharmaceutics, 2022 - mdpi.com
The aim of this research is the development of new colonic release systems of meloxicam
(MLX) a non-steroidal anti-inflammatory drug (NSAIDs) with pH and time-dependent …