Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

Abstract Analysis of premalignant tissue has identified the typical order of somatic events
leading to invasive tumors in several cancer types. For other cancers, premalignant tissue is …

Breast cancer management has witnessed significant advancements, especially in the
diagnosis and treatment response monitoring through the implementation of imaging …

Colon cancer is the third most common cancer worldwide, with high mortality. Adverse side
effects and chemoresistance of the first-line chemotherapy 5-fluorouracil (5-FU) have …

Background Colorectal cancer is one of the most common malignancies in both men and
women. Despite progress in the treatment of the disease, metastatic colorectal cancer …

Background: Comprehensive analysis of PI3K-AKT-mTOR pathway gene alterations in
breast cancer may be helpful for targeted therapy. Methods: We performed targeted …

RNAs and their encoded proteins intricately regulate diverse cell types and states within the
human body. Dysregulated RNA expressions or mutations can lead to various diseased cell …

MicroRNAs (miRNAs/miRs) serve an important role in the pathogenesis of chronic heart
failure (CHF). A number of reports have illustrated the regulatory effect of serum exosomal …

Background: Squamous cervical carcinoma represents an infection-associated malignancy
that produces a high mortality when metastatic or recurrent after primary local treatment …