Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications

MS Castaneto, DA Gorelick, NA Desrosiers… - Drug and alcohol …, 2014 - Elsevier
Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …

The synthetic cannabinoids phenomenon: from structure to toxicological properties. A review

VL Alves, JL Gonçalves, J Aguiar… - Critical Reviews in …, 2020 - Taylor & Francis
The word “cannabinoid” refers to every chemical substance, regardless of structure or origin,
that joins the cannabinoid receptors of the body and brain and that have similar effects to …

Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135

SD Banister, J Stuart, RC Kevin… - ACS Chemical …, 2015 - ACS Publications
Synthetic cannabinoid (SC) designer drugs featuring bioisosteric fluorine substitution are
identified by forensic chemists and toxicologists with increasing frequency. Although …

[HTML][HTML] New synthetic cannabinoids metabolism and strategies to best identify optimal marker metabolites

X Diao, MA Huestis - Frontiers in chemistry, 2019 - frontiersin.org
Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the
endocannabinoid system and as novel pharmacotherapies, but are now highly abused. This …

Detection and activity profiling of synthetic cannabinoids and their metabolites with a newly developed bioassay

A Cannaert, J Storme, F Franz, V Auwärter… - Analytical …, 2016 - ACS Publications
Synthetic cannabinoids (SCs) are the largest group of compounds currently monitored in
Europe by the EU Early Warning System on new psychoactive substances. Emerging …

[HTML][HTML] Cannabinoids: from pot to lab

E Papaseit, C Pérez-Mañá… - … journal of medical …, 2018 - ncbi.nlm.nih.gov
Cannabis is becoming increasingly present in our society. In recent years, the line between
the natural (cannabis) and the synthetic (synthetic cannabinoids), the recreational …

Approaches, challenges, and advances in metabolism of new synthetic cannabinoids and identification of optimal urinary marker metabolites

X Diao, MA Huestis - Clinical Pharmacology & Therapeutics, 2017 - Wiley Online Library
We review approaches for determining metabolism of new synthetic cannabinoids (SCs),
and challenges and advances in identifying optimal urinary marker metabolites of SC intake …

Three fatalities associated with the synthetic cannabinoids 5F-ADB, 5F-PB-22, and AB-CHMINACA

V Angerer, S Jacobi, F Franz, V Auwärter… - Forensic science …, 2017 - Elsevier
The use of synthetic cannabinoids (SC) has been widespread in certain groups of drug
users for many years. In the scientific literature many intoxication cases and a number of …

Synthetic cannabinoids pharmacokinetics and detection methods in biological matrices

MS Castaneto, A Wohlfarth, NA Desrosiers… - Drug metabolism …, 2015 - Taylor & Francis
Synthetic cannabinoids (SC), originally developed as research tools, are now highly abused
novel psychoactive substances. We present a comprehensive systematic review covering in …

Pentylindole/pentylindazole synthetic cannabinoids and their 5-fluoro analogs produce different primary metabolites: metabolite profiling for AB-PINACA and 5F-AB …

A Wohlfarth, MS Castaneto, M Zhu, S Pang… - The AAPS journal, 2015 - Springer
Whereas non-fluoropentylindole/indazole synthetic cannabinoids appear to be metabolized
preferably at the pentyl chain though without clear preference for one specific position, their …