Matrix Metalloproteinases: A challenging paradigm of cancer management

A Alaseem, K Alhazzani, P Dondapati, S Alobid… - Seminars in cancer …, 2019 - Elsevier
Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases
implicated in a variety of physiological and pathological processes. Over the decades …

Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies

S Das, SA Amin, T Jha - European Journal of Medicinal Chemistry, 2021 - Elsevier
Abstract Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are
collectively known as gelatinases whereas MMP-2 is gelatinase-A and MMP-9 is termed as …

Matrix metalloproteinases: their functional role in lung cancer

N Merchant, GP Nagaraju, B Rajitha… - …, 2017 - academic.oup.com
Lung malignancy is the foremost cause of cancer-related deaths globally and is frequently
related to long-term tobacco smoking. Recent studies reveal that the expression of matrix …

Intricate functions of matrix metalloproteinases in physiological and pathological conditions

R Mittal, AP Patel, LH Debs, D Nguyen… - Journal of cellular …, 2016 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a diverse group of proteolytic enzymes and play an
important role in the degradation and remodeling of the extracellular matrix (ECM). In normal …

Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis

Y You, Y Shan, J Chen, H Yue, B You, S Shi… - Cancer …, 2015 - Wiley Online Library
Nasopharyngeal cancer (NPC) is an endemic type of head and neck cancer with a high rate
of cervical lymph node metastasis. Metastasis is the major cause of death in NPC patients …

[HTML][HTML] Validating cell surface proteases as drug targets for cancer therapy: what do we know, and where do we go?

E Verhulst, D Garnier, I De Meester, B Bauvois - Cancers, 2022 - mdpi.com
Simple Summary Cell surface proteases (so-called ectoproteases) are associated with
cancer, and their targeting may confer valuable options for the improvement of cancer …

Cell–matrix interactions: focus on proteoglycan–proteinase interplay and pharmacological targeting in cancer

AD Theocharis, C Gialeli, P Bouris… - The FEBS …, 2014 - Wiley Online Library
Proteoglycans are major constituents of extracellular matrices, as well as cell surfaces and
basement membranes. They play key roles in supporting the dynamic extracellular matrix by …

[HTML][HTML] Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling

Y Gu, J Yu, C Ding, Y Zhou, J Yang, WP Yu… - Journal of …, 2021 - ncbi.nlm.nih.gov
Tumor distant metastasis is the primary cause of death in colorectal cancer (CRC) patients.
GL-V9 is a newly synthesized flavonoid derivative with several beneficial biological …

Influencing COX-2 activity by COX related pathways in inflammation and cancer

T Yu, X Lao, H Zheng - Mini reviews in medicinal chemistry, 2016 - ingentaconnect.com
Cancer is a major cause of death worldwide despite significant advances in surgery and
biology. Several recent studies have suggested that there is a close connection between …

[HTML][HTML] Developing small molecule therapeutics for the initial and adjunctive treatment of snakebite

TC Bulfone, SP Samuel, PE Bickler… - Journal of tropical …, 2018 - hindawi.com
The World Health Organization (WHO) recently added snakebite envenoming to the priority
list of Neglected Tropical Diseases (NTD). It is thought that~ 75% of mortality following …