Diabetes, oxidative stress and therapeutic strategies
L Rochette, M Zeller, Y Cottin, C Vergely - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background Diabetes has emerged as a major threat to health worldwide. Scope of Review
The exact mechanisms underlying the disease are unknown; however, there is growing …
The exact mechanisms underlying the disease are unknown; however, there is growing …
HO-1 overexpression and underexpression: Clinical implications
GS Drummond, J Baum, M Greenberg, D Lewis… - Archives of biochemistry …, 2019 - Elsevier
In this review we examine the effects of both over-and under-production of heme oxygenase-
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …
Single-cell transcriptomic analysis reveals the cellular heterogeneity of mesenchymal stem cells
Ex vivo-expanded mesenchymal stem cells (MSCs) have been demonstrated to be a
heterogeneous mixture of cells exhibiting varying proliferative, multipotential, and …
heterogeneous mixture of cells exhibiting varying proliferative, multipotential, and …
The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease
I Fleming - Pharmacological reviews, 2014 - ASPET
Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …
Translational significance of heme oxygenase in obesity and metabolic syndrome
NG Abraham, JM Junge, GS Drummond - Trends in pharmacological …, 2016 - cell.com
The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic
syndrome. This review reflects the dramatic increase in research on the role of increased …
syndrome. This review reflects the dramatic increase in research on the role of increased …
Epoxyeicosanoids promote organ and tissue regeneration
Epoxyeicosatrienoic acids (EETs), lipid mediators produced by cytochrome P450
epoxygenases, regulate inflammation, angiogenesis, and vascular tone. Despite pleiotropic …
epoxygenases, regulate inflammation, angiogenesis, and vascular tone. Despite pleiotropic …
PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid
Background/objectives Obesity is a risk factor in the development of type 2 diabetes mellitus
(DM2), which is associated with increased morbidity and mortality, predominantly as a result …
(DM2), which is associated with increased morbidity and mortality, predominantly as a result …
Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications
Obesity-mediated metabolic syndrome remains the leading cause of death worldwide.
Among many potential targets for pharmacological intervention, a promising strategy …
Among many potential targets for pharmacological intervention, a promising strategy …
Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet
We examined the hypothesis that adipocyte dysfunction in mice fed a high-fat (HF) diet can
be prevented by lentiviral-mediated and adipocyte specific-targeting delivery of the human …
be prevented by lentiviral-mediated and adipocyte specific-targeting delivery of the human …
Epoxyeicosatrienoic acids regulate adipocyte differentiation of mouse 3T3 cells, via PGC-1α activation, which is required for HO-1 expression and increased …
Epoxyeicosatrienoic acid (EET) contributes to browning of white adipose stem cells to
ameliorate obesity/diabetes and insulin resistance. In the current study, we show that EET …
ameliorate obesity/diabetes and insulin resistance. In the current study, we show that EET …