A system for programmable export of RNA molecules from living cells would enable both
non-destructive monitoring of cell dynamics and engineering of cells capable of delivering …

Noncoding RNA genes produce a functional RNA product rather than a translated protein.
More than 1500 homologs of known “classical” RNA genes can be annotated in the human …

Publisher Summary This chapter focuses on the concept of human immunodeficiency virus
type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process …

Assembly of retrovirus particles normally entails the selective encapsidation of viral genomic
RNA. However, in the absence of packageable viral RNA, assembly is still efficient, and the …

Next-generation sequencing is a valuable tool in our growing understanding of the genetic
diversity of viral populations. Using this technology, we have investigated the RNA content of …

In addition to genomic RNA, HIV-1 particles package cellular and spliced viral RNAs. In
order to determine the encapsidation mechanisms of these RNAs, we determined the …

Small nuclear RNAs (snRNAs) are structural and functional cores of the spliceosome. In
metazoan genomes, each snRNA has multiple copies/variants, up to hundreds in mammals …

As they assemble, retroviruses encapsidate both their genomic RNAs and several types of
host RNA. Whereas limited amounts of messenger RNA (mRNA) are detectable within virion …

All retroviruses package cellular RNAs into virions. Studies of murine leukemia virus (MLV)
revealed that the major host cell RNAs encapsidated by this simple retrovirus were LTR …

Retroviral Gag polyproteins coopt host factors to traffic from cytosolic ribosomes to the
plasma membrane, where virions are released. Before membrane transport, the …