Peripheral insulin resistance (IR) is a well-documented, independent risk factor for the
development of type 2 diabetes, cardiovascular disease, cancer and cellular senescence …

Pathomechanisms of dementias involve increasing damage to neuronal energy metabolism,
resulting in degeneration‐related insulin resistance and glucose hypometabolism. In this …

Neurovascular coupling (NVC) is an important mechanism to ensure adequate blood supply
to active neurons in the brain. NVC damage can lead to chronic impairment of neuronal …

Understanding the molecular underpinnings of neurodegeneration processes is a pressing
challenge for medicine and neurobiology. Alzheimer's disease (AD) and Parkinson's …

Abstract Alzheimer's disease (AD), characterized by cognitive dysfunction and other
behavioral abnormalities, is a progressive neurodegenerative disease that occurs due to …

Alzheimer's disease (AD) is a neurodegenerative olfactory disorder affecting millions of
people worldwide. Alterations in the hexosamine-or glucose-related pathways have been …

Astrocytes play fundamental roles in the maintenance of brain homeostasis. The dysfunction
of these cells is widely associated with brain disorders, which are often characterized by …

Neurometabolic homeostasis in the brain relies on the dynamic transport of glucose and
other substrates across brain barriers, primarily the blood–brain barrier and the blood …

The disease's trajectory of Alzheimer's disease (AD) is associated with and worsened by
hippocampal hyperexcitability. Here we show that during the asymptomatic stage in a knock …

Background Impaired brain glucose metabolism is a preclinical feature of
neurodegenerative diseases such as Alzheimer's disease (AD). Infections may promote AD …