Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …

The contribution of natural products (NPs) to drug development has been extensively
documented. The structural diversity and biological activity of NPs make them the most …

A unified synthetic approach was developed that enabled the synthesis of diverse tropane-
related scaffolds. The key intermediates that were exploited were cycloadducts formed by …

Diversity-Oriented Synthesis (DOS) consists of generating structurally diverse compounds
from a complexity-generating reaction followed by cyclization steps and appendage …

The escalating crisis of antimicrobial resistance (AMR) underscores the urgent need for
novel antimicrobials. One promising strategy is the exploration of structural diversity, as …

Diversity-Oriented Synthesis (DOS) represents a strategy to obtain molecule libraries with
diverse structural features starting from one common compound in limited steps of synthesis …

A strategy for photochemical oxidative cleavage of the aminomethylene group at the C2
position of indole was developed to synthesize C2-carbonyl indoles. The reaction was …

The build/couple/pair strategy was applied to the generation of 18 structurally diverse
scaffolds built around pyrrole cores. The couple phase, involving the first application of a …

The ongoing threat of Antimicrobial Resistance (AMR) complicated by the rise of Multidrug-
Resistant (MDR) pathogens calls for increased efforts in the search for novel treatment …