Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Antimicrobial strategies centered around reactive oxygen species–bactericidal antibiotics, photodynamic therapy, and beyond

F Vatansever, WCMA de Melo, P Avci… - FEMS microbiology …, 2013 - academic.oup.com
Reactive oxygen species (ROS) can attack a diverse range of targets to exert antimicrobial
activity, which accounts for their versatility in mediating host defense against a broad range …

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

C Lood, LP Blanco, MM Purmalek… - Nature medicine, 2016 - nature.com
Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are
generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune …

Lentiviral gene therapy for X-linked chronic granulomatous disease

DB Kohn, C Booth, EM Kang, SY Pai, KL Shaw… - Nature medicine, 2020 - nature.com
Chronic granulomatous disease (CGD) is a rare inherited disorder of phagocytic cells,. We
report the initial results of nine severely affected X-linked CGD (X-CGD) patients who …

A review of chronic granulomatous disease

DE Arnold, JR Heimall - Advances in therapy, 2017 - Springer
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in
any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst …

Reactive oxygen species: from health to disease

K Brieger, S Schiavone, FJ Miller Jr, KH Krause - Swiss medical weekly, 2012 - smw.ch
Upon reaction with electrons, oxygen is transformed into reactive oxygen species (ROS). It
has long been known that ROS can destroy bacteria and destroy human cells, but research …

[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach… - Redox biology, 2017 - Elsevier
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Free radicals and related reactive species as mediators of tissue injury and disease: implications for health

JP Kehrer, LO Klotz - Critical reviews in toxicology, 2015 - Taylor & Francis
A radical is any molecule that contains one or more unpaired electrons. Radicals are normal
products of many metabolic pathways. Some exist in a controlled (caged) form as they …

Neutrophil function: from mechanisms to disease

B Amulic, C Cazalet, GL Hayes… - Annual review of …, 2012 - annualreviews.org
Neutrophils are the most abundant white blood cells in circulation, and patients with
congenital neutrophil deficiencies suffer from severe infections that are often fatal …

[HTML][HTML] Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms

B Kalyanaraman - Redox biology, 2013 - Elsevier
This article provides a succinct but limited overview of the protective and deleterious effects
of reactive oxygen and nitrogen species in a clinical context. Reactive oxygen species …