Drug delivery to the posterior segment of the eye: biopharmaceutic and pharmacokinetic considerations

R Varela-Fernández, V Díaz-Tomé… - Pharmaceutics, 2020 - mdpi.com
The treatment of the posterior-segment ocular diseases, such as age-related eye diseases
(AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the …

EMT and EndMT: emerging roles in age-related macular degeneration

DY Shu, E Butcher, M Saint-Geniez - International journal of molecular …, 2020 - mdpi.com
Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT)
are physiological processes required for normal embryogenesis. However, these processes …

Ocular sarcoidosis

S Pasadhika, JT Rosenbaum - Clinics in chest medicine, 2015 - chestmed.theclinics.com
Ocular involvement of sarcoidosis has been known since the early 1900s and has become
more recognized since the mid-1900s. 1 Variability in the diagnostic criteria has made …

Immunosuppression for the Uveitides

DA Jabs - Ophthalmology, 2018 - Elsevier
The uveitides are a collection of more than 30 diseases characterized by intraocular
inflammation. Many cases of juvenile idiopathic arthritis–associated uveitis, many cases of …

[HTML][HTML] Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitis (FOCUS) initiative

AD Dick, JT Rosenbaum, HA Al-Dhibi, R Belfort Jr… - Ophthalmology, 2018 - Elsevier
Topic An international, expert-led consensus initiative to develop systematic, evidence-
based recommendations for the treatment of noninfectious uveitis in the era of biologics …

The Ocular Immunology and Uveitis Foundation preferred practice patterns of uveitis management

CS Foster, S Kothari, SD Anesi, AT Vitale, D Chu… - Survey of …, 2016 - Elsevier
Ocular inflammatory disease is a leading cause of vision loss worldwide. Uveitis
encompasses a wide spectrum of pathology, both with respect to its etiology and the …

Effect of corticosteroid-sparing treatment with mycophenolate mofetil vs methotrexate on inflammation in patients with uveitis: a randomized clinical trial

SR Rathinam, JA Gonzales, R Thundikandy… - Jama, 2019 - jamanetwork.com
Importance Methotrexate and mycophenolate mofetil are commonly used
immunomodulatory therapies for achieving corticosteroid-sparing control of noninfectious …

Mucous membrane pemphigoid

HH Xu, VP Werth, E Parisi, TP Sollecito - Dental Clinics, 2013 - dental.theclinics.com
Mucous membrane pemphigoid (MMP) is a heterogeneous group of chronic, autoimmune
subepithelial blistering diseases that predominantly involves the mucous membranes and …

Update on the use of systemic biologic agents in the treatment of noninfectious uveitis

S Pasadhika, JT Rosenbaum - Biologics: Targets and Therapy, 2014 - Taylor & Francis
Uveitis is one of the leading causes of blindness worldwide. Noninfectious uveitis may be
associated with other systemic conditions, such as human leukocyte antigen B27-related …

Cyclosporine for ocular inflammatory diseases

RO Kaçmaz, JH Kempen, C Newcomb, E Daniel… - Ophthalmology, 2010 - Elsevier
PURPOSE: To evaluate the clinical outcomes of cyclosporine treatment for noninfectious
ocular inflammation. DESIGN: Retrospective cohort study. PARTICIPANTS: A total of 373 …