[HTML][HTML] Organoids
Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …
aspects of the complex structure and function of the corresponding in vivo tissue. They can …
Cell–extracellular matrix mechanotransduction in 3D
A Saraswathibhatla, D Indana… - Nature Reviews Molecular …, 2023 - nature.com
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …
including differentiation, migration and proliferation, through mechanotransduction. Studies …
The role of goblet cells and mucus in intestinal homeostasis
JK Gustafsson, MEV Johansson - Nature reviews Gastroenterology & …, 2022 - nature.com
The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …
Tissue geometry drives deterministic organoid patterning
INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that
have enormous potential as models for human organ development and disease, as …
have enormous potential as models for human organ development and disease, as …
Next-generation cancer organoids
Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …
cancer heterogeneity and its implications for personalized medicine. These advancements …
High cell density and high-resolution 3D bioprinting for fabricating vascularized tissues
Three-dimensional (3D) bioprinting techniques have emerged as the most popular methods
to fabricate 3D-engineered tissues; however, there are challenges in simultaneously …
to fabricate 3D-engineered tissues; however, there are challenges in simultaneously …
[HTML][HTML] Engineering organoids
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …
enormous interest for modelling tissue development and disease, and for personalized …
Human neural tube morphogenesis in vitro by geometric constraints
Understanding human organ formation is a scientific challenge with far-reaching medical
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …
[HTML][HTML] Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration
Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …
attention as a way to better mimic the complex interactions between individual cells and the …
[HTML][HTML] Intestinal organoid cocultures with microbes
J Puschhof, C Pleguezuelos-Manzano… - Nature protocols, 2021 - nature.com
Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables
the study of host–microbe interactions with great experimental control. This protocol …
the study of host–microbe interactions with great experimental control. This protocol …