Nanomaterials offer unique physical, chemical and biological properties of interest for
medical imaging and therapy. Over the last two decades, there has been an increasing effort …

Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …

Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …

Aim: A nanoemulsion loaded with memantine for intranasal delivery to bypass the blood-
brain barrier for the treatment of Alzheimer disease. Method: The nanoemulsion was …

The present work focuses on the development of surface modified transferrin PLGA
nanoparticles loaded with clonidine for nose to brain delivery. The CLD-Tf-PLGA-NPs were …

Direct nose-to-brain delivery of drugs and faster onset of action have made intra-nasal route
a much sought-after alternative to conventional routes of drug delivery to the brain …

Diabetic neuropathy is the most entrenched complication of diabetes. Usually, it affects the
distal foot and toes, which then gradually approaches the lower part of the legs. Diabetic foot …

Background: Intranasal administration of biodegradable nanoparticles has been extensively
studied for targeting the drug directly to CNS through the olfactory or trigeminal route …

Alzheimer's disease is becoming a common disorder of the elderly population due to
shrinkage of the brain size with age and many other neurological complications. To provide …

Delivering drugs to the brain has always been a challenging task due to the restrictive
properties of the blood-brain barrier (BBB). Intranasal delivery is therefore emerging as an …