Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs),
are initiated by end resection that generates 3′ single strands. This reaction is shared, at …

Immunoglobulin (Ig) class switch recombination (CSR) is the process occurring in mature B
cells that diversifies the effector component of antibody responses. CSR is initiated by the …

Even though radiotherapy is the most important therapeutic strategy for colon cancer
treatment, there is an enormous demand to improve radiosensitivity in solid tumor …

DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) has been implicated in the
repair of chromosome breaks, but its cellular mechanism and role relative to canonical …

Here we report that PTEN contributes to DNA double-strand break (DSB) repair via
homologous recombination (HR), as evidenced by (i) inhibition of HR in a reporter plasmid …

The regulation of DNA double-strand breaks (DSBs) and telomeres are diametrically
opposed in the cell. DSBs are considered one of the most deleterious forms of DNA damage …

Abstract Mutations in histone H3. 3‐encoding genes causing mutant histone tails are
associated with specific cancers such as pediatric glioblastomas (H3. 3‐G34R/V) and giant …

DNA double-strand breaks (DSBs) occur in our cells in the context of chromatin. This type of
lesion is toxic, entirely preventing genome continuity and causing cell death or terminal …

Classical nonhomologous end joining (C-NHEJ) repairs DNA double-strand breaks (DSBs)
throughout interphase but predominates in G1 phase when homologous recombination is …

Simple Summary Colorectal cancer (CRC) is among the most common cancers and the third
leading cause of cancer deaths worldwide. Despite the identification of alterations in DNA …