Regulation of homologous recombination (HR) is central for cancer prevention. However,
too little HR can increase cancer incidence, whereas too much HR can drive cancer …

SWI/SNF complexes are among the most studied ATP-dependent chromatin remodeling
complexes, mostly due to their critical role in coordinating chromatin architecture and gene …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage.
Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of …

Background Homologous recombination deficiency (HRD) is a phenotype that is
characterized by the inability of a cell to effectively repair DNA double-strand breaks using …

Background Homologous recombination repair deficiency (HRD) is a frequent feature of
high-grade serous ovarian, fallopian tube and peritoneal carcinoma (HGSC) and is …

Cancers with deficiencies in homologous recombination-mediated DNA repair (HRR)
demonstrate improved clinical outcomes and increased survival. Approximately 50% of high …

Optimal treatment of cancer requires diagnostic methods to facilitate therapy choice and
prevent ineffective treatments. Direct assessment of therapy response in viable tumor …

Purpose: To determine the ability of RAD51 foci to predict platinum chemotherapy response
in high-grade serous ovarian cancer (HGSOC) patient-derived samples. Experimental …

Epithelial ovarian cancer (EOC) patients are generally diagnosed at an advanced stage,
usually relapse after initial treatments, which include debulking surgery and adjuvant …

Simple Summary Breast cancer is the most frequently occurring cancer worldwide. With the
help of next-generation sequencing, the development of biomedical technologies and the …