Mechanisms of action of currently used antiseizure drugs

GJ Sills, MA Rogawski - Neuropharmacology, 2020 - Elsevier
Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol

P Alves, C Amaral, N Teixeira… - Pharmacological …, 2020 - Elsevier
Cannabis is the most used illicit drug worldwide and its medicinal use is under discussion,
being regulated in several countries. However, the psychotropic effects of Δ 9 …

Recent advances in Cannabis sativa genomics research

B Hurgobin, M Tamiru‐Oli, MT Welling… - New …, 2021 - Wiley Online Library
Cannabis (Cannabis sativa L.) is one of the oldest cultivated plants purported to have
unique medicinal properties. However, scientific research of cannabis has been restricted by …

Pharmacoresistance–Epidemiology, mechanisms, and impact on epilepsy treatment

M Janmohamed, MJ Brodie, P Kwan - Neuropharmacology, 2020 - Elsevier
Understanding the natural history of and factors associated with pharmacoresistant epilepsy
provides the foundation for formulating mechanistic hypotheses that can be evaluated to …

Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions

LL Anderson, NL Absalom, SV Abelev, IK Low… - …, 2019 - Wiley Online Library
Objective Cannabidiol (CBD) has been approved by the US Food and Drug Administration
(FDA) to treat intractable childhood epilepsies, such as Dravet syndrome and Lennox …

The Genomics of Cannabis and Its Close Relatives

I Kovalchuk, M Pellino, P Rigault… - Annual Review of …, 2020 - annualreviews.org
Cannabis sativa L. is an important yet controversial plant with a long history of recreational,
medicinal, industrial, and agricultural use, and together with its sister genus Humulus, it …

[HTML][HTML] Effects of chronic cannabidiol treatment in the rat chronic unpredictable mild stress model of depression

Z Gáll, S Farkas, Á Albert, E Ferencz, S Vancea… - Biomolecules, 2020 - mdpi.com
Several neuropharmacological actions of cannabidiol (CBD) due to the modulation of the
endocannabinoid system as well as direct serotonergic and gamma-aminobutyric acidergic …

[HTML][HTML] The molecular mechanisms that underpin the biological benefits of full-spectrum cannabis extract in the treatment of neuropathic pain and inflammation

ZH Maayah, S Takahara, M Ferdaoussi… - Biochimica Et Biophysica …, 2020 - Elsevier
Cannabis has been shown to be beneficial in the treatment of pain and inflammatory
diseases. The biological effect of cannabis is mainly attributed to two major cannabinoids …

A randomized controlled trial of topical cannabidiol for the treatment of thumb basal joint arthritis

JT Heineman, GL Forster, KL Stephens… - The Journal of hand …, 2022 - Elsevier
Purpose Since the passage of the Agricultural Improvement Act of 2018, hand surgeons
have increasingly encountered patients seeking counseling on over-the-counter, topical …

[HTML][HTML] Cannabidiol and cannabigerol exert antimicrobial activity without compromising skin microbiota

M Luz-Veiga, M Amorim, I Pinto-Ribeiro… - International Journal of …, 2023 - mdpi.com
Cannabidiol (CBD) and cannabigerol (CBG) are two pharmacologically active
phytocannabinoids of Cannabis sativa L. Their antimicrobial activity needs further …