[HTML][HTML] The role of melatonin in the development of postmenopausal osteoporosis

K Yang, X Qiu, L Cao, S Qiu - Frontiers in pharmacology, 2022 - frontiersin.org
Melatonin is an important endogenous hormone that modulates homeostasis in the
microenvironment. Recent studies have indicated that serum melatonin levels are closely …

The interplay between the PI3K/AKT pathway and circadian clock in physiologic and cancer‐related pathologic conditions

MR Khezri, HY Hsueh, S Mohammadipanah… - Cell …, 2024 - Wiley Online Library
The circadian clock is responsible for the regulation of different cellular processes, and its
disturbance has been linked to the development of different diseases, such as cancer. The …

Phosphorylation of DNA-binding domains of CLOCK–BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells

Y Otobe, EM Jeong, S Ito… - Proceedings of the …, 2024 - National Acad Sciences
In mammals, CLOCK and BMAL1 proteins form a heterodimer that binds to E-box
sequences and activates transcription of target genes, including Period (Per). Translated …

[HTML][HTML] Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks

M Dudek, DRJ Pathiranage, B Bano-Otalora… - Nature …, 2023 - nature.com
Daily rhythms in mammalian behaviour and physiology are generated by a multi-oscillator
circadian system entrained through environmental cues (eg light and feeding). The …

[PDF][PDF] SI Materials and Methods 3

IQTLGE Healthcare - pdfs.semanticscholar.org
Detection of CLOCK protein in NIH3T3 cells was performed as previously 5 described (1, 2)
with some modifications. NIH3T3 cells were plated on 10-cm dishes. 6 After 48 h, all media …