Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
JL Stobart, CM Anderson - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Dynamic adjustments to neuronal energy supply in response to synaptic activity are critical
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …
Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches
S Shekhar, MW Cunningham, MR Pabbidi… - European journal of …, 2018 - Elsevier
Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic
options. However, accumulating evidence indicates a central role of inflammation in all …
options. However, accumulating evidence indicates a central role of inflammation in all …
Emerging therapies in traumatic brain injury
PM Kochanek, TC Jackson, NM Ferguson… - Seminars in …, 2015 - thieme-connect.com
Despite decades of basic and clinical research, treatments to improve outcomes after
traumatic brain injury (TBI) are limited. However, based on the recent recognition of the …
traumatic brain injury (TBI) are limited. However, based on the recent recognition of the …
Contribution of flow-dependent vasomotor mechanisms to the autoregulation of cerebral blood flow
A Koller, P Toth - Journal of vascular research, 2012 - karger.com
Regulation of cerebral blood flow (CBF) is the result of multilevel mechanisms to maintain
the appropriate blood supply to the brain while having to comply with the limited space …
the appropriate blood supply to the brain while having to comply with the limited space …
Novel mechanistic insights and potential therapeutic impact of TRPC6 in neurovascular coupling and ischemic stroke
Ischemic stroke is one of the most disabling diseases and a leading cause of death globally.
Despite advances in medical care, the global burden of stroke continues to grow, as no …
Despite advances in medical care, the global burden of stroke continues to grow, as no …
[HTML][HTML] Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology
Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to
epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and …
epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and …
Inflammation in ischemic stroke: mechanisms, consequences and possible drug targets
Ischemic stroke is caused when blood flow to the brain is hampered, leading to instant
deficiency of nutrients and oxygen required for normal brain functioning. Reperfusion can …
deficiency of nutrients and oxygen required for normal brain functioning. Reperfusion can …
Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats
KM Dunn, M Renic, AK Flasch… - American Journal …, 2008 - journals.physiology.org
Hypertension is a major risk factor for stroke, but the factors that contribute to the increased
incidence and severity of ischemic stroke in hypertension remain to be determined. 20 …
incidence and severity of ischemic stroke in hypertension remain to be determined. 20 …
Eicosanoids and their drugs in cardiovascular diseases: focus on atherosclerosis and stroke
Eicosanoids are biologically active lipids in both physiologic and pathophysiologic
situations. These mediators rapidly generate at sites of inflammation and act through specific …
situations. These mediators rapidly generate at sites of inflammation and act through specific …
Inflammation after stroke: mechanisms and therapeutic approaches
Reperfusion of ischemic brain can reduce injury and improve outcome, but secondary injury
due to inflammatory mechanisms limits the efficacy and time window of such treatments for …
due to inflammatory mechanisms limits the efficacy and time window of such treatments for …