Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation
that plays a major role in immunosenescence and in development and progression of many …

The plasminogen activator (PA) system is an extracellular proteolytic enzyme system
associated with various physiological and pathophysiological processes. A large body of …

The plasminogen system has been implicated in clot lysis, wound healing, tissue
regeneration, cancer and many other processes that affect health and disease. The …

The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and
elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in …

The murine Ly6 complex was identified 35 years ago using antisera to lymphocytes. With
advances in mAb development, molecular cloning, and genome sequencing,> 20 …

Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Once escaped from the quiescence niche, precursor cells interact with stromal components
that support their survival, proliferation, and differentiation. We examined interplays between …

Purpose Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR)
positively correlate with the activation level of the immune system. We reviewed the …