Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

The second edition of the" go-to" reference in this field is completely updated and features
more than 80% new content, with emphasis on new developments in the field, especially in …

We have designed a highly specific inhibitor of calpain by mimicking a natural protein–
protein interaction between calpain and its endogenous inhibitor calpastatin. To enable this …

Overexpressed pro-survival B-cell lymphoma-2 (BCL-2) family proteins BCL-2 and BCL-XL
can render tumor cells malignant. Leukemia drug venetoclax is currently the only approved …

Herein we review contemporary synthetic and protein design strategies to stabilize the α-
helical motif in short peptides and miniature proteins. Advances in organometallic catalyst …

Macrocyclic peptides represent attractive scaffolds for targeting protein–protein interactions,
making methods for the diversification and functional selection of these molecules highly …

Macrocyclic peptides (MPs) have positioned themselves as a privileged class of compounds
for the discovery of therapeutics and development of chemical probes. Aided by the …

Although many cellular processes depend upon enzymatic reactions, protein–protein
interactions (PPIs) mediate a large number of important regulatory pathways and thus play a …

α-Helices constitute the largest class of protein secondary structures and play a major role in
mediating protein− protein interactions. Development of stable mimics of short α-helices …