The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

Lung cancer is an umbrella term for a subset of heterogeneous diseases that are collectively
responsible for the most cancer-related deaths worldwide. Despite the tremendous progress …

Background Vorinostat is a histone deacetylase inhibitor that changes gene expression and
protein activity. On the basis of the clinical benefit reported in patients with malignant pleural …

To overcome the side effects of and resistance to cisplatin, a variety of Pt (IV) prodrugs were
designed and synthesized via different modifications including combination with lipid chains …

It is well known that oxidative stress can lead to chronic inflammation which, in turn, could
mediate most chronic diseases including cancer. Oxidants have been implicated in the …

Pemetrexed (ALIMTA, Lilly) is a folate antimetabolite that has been approved by the US
Food and Drug Administration for the treatment of non–small cell lung cancer and has been …

Abstract Objectives Tumor Treating Fields (TTFields) are low intensity, intermediate
frequency, alternating electric fields with antimitotic effects on cancerous cells. TTFields …

Malignant pleural mesothelioma is a highly aggressive cancer with a very poor prognosis.
Although the mechanism of carcinogenesis is not fully understood, approximately 80% of …

Malignant mesothelioma (MM) is a relatively rare cancer that occurs almost exclusively
following respiratory exposure to asbestos in humans. Its pathogenesis is closely associated …

One of the most promising strategies to increase the efficacy of standard chemotherapy
drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis) …