Anti-cancer palladium complexes: a focus on PdX 2 L 2, palladacycles and related complexes

AR Kapdi, IJS Fairlamb - Chemical Society Reviews, 2014 - pubs.rsc.org
Much success has been achieved with platinum-based chemotherapeutic agents, ie through
interactions with DNA. The long-term application of Pt complexes is thwarted by issues …

The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

H Beraldo, D Gambino - Mini reviews in medicinal chemistry, 2004 - europepmc.org
The more significant bioactivities of a variety of semicarbazones (anti-protozoa,
anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and …

Synthesis of palladium (II) complexes via Michael addition: antiproliferative effects through ROS-mediated mitochondrial apoptosis and docking with SARS-CoV-2

J Haribabu, S Srividya, D Mahendiran… - Inorganic …, 2020 - ACS Publications
Metal complexes have numerous applications in the current era, particularly in the field of
pharmaceutical chemistry and catalysis. A novel synthetic approach for the same is always a …

Palladium coordination compounds as anti-viral, anti-fungal, anti-microbial and anti-tumor agents

A Garoufis, SK Hadjikakou, N Hadjiliadis - Coordination Chemistry Reviews, 2009 - Elsevier
Pd (II) complexes of various donor atom ligands posses anti-tumor and anti-viral,-malarial,-
fungal and-microbial activities. This review focuses on such properties of Pd (II) complexes …

Platinum group antitumor chemistry: design and development of new anticancer drugs complementary to cisplatin

AS Abu-Surrah, M Kettunen - Current medicinal chemistry, 2006 - ingentaconnect.com
In the next two decades, the world is expected to see around 20 million cases of cancer.
Moreover, the types of cancer will vary considerably from country to other. Therefore, all …

In vitro and in vivo anticancer activity of copper bis (thiosemicarbazone) complexes

D Palanimuthu, SV Shinde… - Journal of medicinal …, 2013 - ACS Publications
Neutral and cationic copper bis (thiosemicarbazone) complexes bearing methyl, phenyl, and
hydrogen, on the diketo-backbone of the ligand have been synthesized. All of them were …

Synthesis, characterization, and in vitro anticancer activity of copper and zinc bis (thiosemicarbazone) complexes

R Anjum, D Palanimuthu, DS Kalinowski… - Inorganic …, 2019 - ACS Publications
A series of eight bis (thiosemicarbazone) ligands and 16 of their respective copper (II) and
zinc (II) complexes containing a combination of hydrogen, methyl, pyridyl, phenyl, and/or …

Comprehensive review on tumour active palladium compounds and structure–activity relationships

MN Alam, F Huq - Coordination Chemistry Reviews, 2016 - Elsevier
This article provides a comprehensive review of palladium compounds that have been
evaluated for anticancer activity in vivo or in vitro from the era of discovery of cisplatin up to …

Platinum (II) complexes with 2-acetyl pyridine thiosemicarbazone: synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity

D Kovala-Demertzi, MA Demertzis, JR Miller… - Journal of Inorganic …, 2001 - Elsevier
An interesting series of new platinum complexes has been synthesized by the reaction of
Na2PtCl4 with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes,[Pt …

[PDF][PDF] Palladium-based chemotherapeutic agents: Routes toward complexes with good antitumor activity

AS Abu-Surrah, HH Al-Sa'doni, MY Abdalla - Cancer Ther, 2008 - academia.edu
Summary Chemical-, pharmacological-, and clinical-research on anticancer coordination
complexes has yielded remarkable anticancer agents such as cisplatin, carboplatin, and …