Inflammation, obesity, and thrombosis

F Samad, W Ruf - Blood, The Journal of the American Society …, 2013 - ashpublications.org
Clinical and epidemiological studies support a connection between obesity and thrombosis,
involving elevated expression of the prothrombotic molecules plasminogen activator …

Obesity and free fatty acids

G Boden - Endocrinology and metabolism clinics of North America, 2008 - Elsevier
Plasma free fatty acid (FFA) levels are elevated in obesity. FFAs cause insulin resistance in
all major insulin target organs (skeletal muscle, liver, endothelial cells) and have emerged …

[HTML][HTML] Hyperglycemia: a prothrombotic factor?

BA Lemkes, J Hermanides, JH DeVries… - Journal of Thrombosis …, 2010 - Elsevier
Diabetes mellitus is characterized by a high risk of atherothrombotic events. What is more,
venous thrombosis has also been found to occur more frequently in this patient group. This …

Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor

A Tenenbaum, R Klempfner, EZ Fisman - Cardiovascular diabetology, 2014 - Springer
The existence of an independent association between elevated triglyceride (TG) levels,
cardiovascular (CV) risk and mortality has been largely controversial. The main difficulty in …

Diabetes mellitus and thrombosis

N Vazzana, P Ranalli, C Cuccurullo, G Davì - Thrombosis research, 2012 - Elsevier
Atherothrombosis is the leading cause of morbidity and mortality in patients with diabetes
mellitus. Several mechanisms contribute to the diabetic prothrombotic state, including …

Coagulation and fibrinolysis in diabetes

SH Alzahrani, RA Ajjan - Diabetes and Vascular Disease …, 2010 - journals.sagepub.com
Atherothrombotic complications are the main cause of mortality in subjects with diabetes.
Premature atherosclerosis, increased platelet reactivity and activation of coagulation factors …

Role of adipose tissue in haemostasis, coagulation and fibrinolysis

DR Faber, PHG De Groot, FLJ Visseren - Obesity reviews, 2009 - Wiley Online Library
Obesity is associated with an increased incidence of insulin resistance (IR), type 2 diabetes
mellitus and cardiovascular diseases. The increased risk for cardiovascular diseases could …

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk

K Kearney, D Tomlinson, K Smith, R Ajjan - Cardiovascular diabetology, 2017 - Springer
An enhanced thrombotic environment and premature atherosclerosis are key factors for the
increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed …

Diabetes and sepsis: preclinical findings and clinical relevance

P Schuetz, P Castro, NI Shapiro - Diabetes care, 2011 - Am Diabetes Assoc
Because of its high prevalence and potential to alter critical elements of sepsis
pathophysiology, diabetes is likely an important comorbid condition in this disease; yet the …

Inflammation and thrombosis in diabetes

K Hess, PJ Grant - Thrombosis and haemostasis, 2011 - thieme-connect.com
Patients with diabetes mellitus are at increased risk of cardiovascular morbidity and
mortality. Atherothrombosis, defined as atherosclerotic lesion disruption with superimposed …