Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

T Kenakin, LJ Miller - Pharmacological reviews, 2010 - ASPET
It is useful to consider seven transmembrane receptors (7TMRs) as disordered proteins able
to allosterically respond to a number of binding partners. Considering 7TMRs as allosteric …

GB virus C: the good boy virus?

N Bhattarai, JT Stapleton - Trends in microbiology, 2012 - cell.com
GB virus C (GBV-C) is a lymphotropic human virus discovered in 1995 that is related to
hepatitis C virus (HCV). GBV-C infection has not been convincingly associated with any …

HIV and the chemokine system: 10 years later

P Lusso - The EMBO journal, 2006 - embopress.org
The unexpected encounter, 10 years ago, between human immunodeficiency virus (HIV)
and the chemokine system has dramatically advanced our understanding of the …

Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication

Y Yu, Z Wan, JH Wang, X Yang, C Zhang - Virulence, 2022 - Taylor & Francis
ABSTRACT Human pegivirus (HPgV-1), previously known as GB virus C (GBV-C) or
hepatitis G virus (HGV), is a single-stranded positive RNA virus belonging to the genus …

Coinfection with hepatitis C virus and human immunodeficiency virus: virological, immunological, and clinical outcomes

Y Rotman, TJ Liang - Journal of virology, 2009 - Am Soc Microbiol
Infection with hepatitis C virus (HCV) is estimated to affect 2% of the world population (90)
and is a leading cause of liver-related morbidity and mortality. Human immunodeficiency …

[HTML][HTML] Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection

JR Larrubia, S Benito-Martínez, M Calvino… - World journal of …, 2008 - ncbi.nlm.nih.gov
Chemokines produced in the liver during hepatitis C virus (HCV) infection induce migration
of activated T cells from the periphery to infected parenchyma. The milieu of chemokines …

Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo

G Thoma, MB Streiff, J Kovarik, F Glickman… - Journal of medicinal …, 2008 - ACS Publications
The interaction of the chemokine receptor CXCR4 with its ligand CXCL12 is involved in
many biological processes such as hematopoesis, migration of immune cells, as well as in …

Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection

ET Chivero, JT Stapleton - Journal of General Virology, 2015 - microbiologyresearch.org
Human pegivirus (HPgV; originally called GB virus C/hepatitis G virus) is an RNA virus
within the genus Pegivirus of the family Flaviviridae that commonly causes persistent …

GB virus type C interactions with HIV: the role of envelope glycoproteins

EL Mohr, JT Stapleton - Journal of viral hepatitis, 2009 - Wiley Online Library
GB virus C/hepatitis G virus (GBV‐C/HGV) is the most closely related human virus to
hepatitis C virus (HCV). GBV‐C is lymphotropic and not associated with any known disease …

The N ational H eart, L ung, and B lood I nstitute R ecipient E pidemiology and D onor E valuation S tudy (REDS‐III): a research program striving to improve blood …

S Kleinman, MP Busch, EL Murphy, H Shan… - …, 2014 - Wiley Online Library
Background The R ecipient E pidemiology and D onor E valuation S tudy‐III (REDS‐III) is a
7‐year multicenter transfusion safety research initiative launched in 2011 by the N ational H …