The extracellular matrix as a multitasking player in disease
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
MicroRNA and cancer–a brief overview
MicroRNAs (miRNAs) are short non-coding RNAs with a length of∼ 22 nucleotides,
involved in posttranscriptional regulation of gene expression. Until now, over 2588 miRNAs …
involved in posttranscriptional regulation of gene expression. Until now, over 2588 miRNAs …
Proteoglycans remodeling in cancer: Underlying molecular mechanisms
AD Theocharis, NK Karamanos - Matrix Biology, 2019 - Elsevier
Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …
components of extracellular matrix playing key roles in its structural organization and cell …
[HTML][HTML] Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of …
In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly …
molecules that regulate several cell functions either by the genomic pathway acting directly …
The wound healing, chronic fibrosis, and cancer progression triad
B Rybinski, J Franco-Barraza… - Physiological …, 2014 - journals.physiology.org
For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …
commonalities that tumors and wounded tissues share, the process of wound healing also …
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …
Dissecting the role of hyaluronan synthases in the tumor microenvironment
The tumor microenvironment is becoming a crucial factor in determining the aggressiveness
of neoplastic cells. The glycosaminoglycan hyaluronan is one of the principal constituents of …
of neoplastic cells. The glycosaminoglycan hyaluronan is one of the principal constituents of …
Versican and versican-matrikines in cancer progression, inflammation, and immunity
Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer
development, ranging from proliferative signaling, evasion of growth-suppressor pathways …
development, ranging from proliferative signaling, evasion of growth-suppressor pathways …
[HTML][HTML] Friend or foe: the role of microRNA in chemotherapy resistance
Chemotherapy has been widely used in treating cancer patients. Despite the tremendous
progress in cancer treatment achieved during the last decades, drug resistance still …
progress in cancer treatment achieved during the last decades, drug resistance still …
[HTML][HTML] Proteoglycans—biomarkers and targets in cancer therapy
Proteoglycans (PGs), important constituents of the extracellular matrix, have been
associated with cancer pathogenesis. Their unique structure consisting of a protein core and …
associated with cancer pathogenesis. Their unique structure consisting of a protein core and …