A mini-review of flavone isomers apigenin and genistein in prostate cancer treatment

X Ji, K Liu, Q Li, Q Shen, F Han, Q Ye… - Frontiers in …, 2022 - frontiersin.org
The initial responses to standard chemotherapies among prostate cancer (PCa) patients are
usually significant, while most of them will finally develop drug resistance, rendering them …

Targeting the IGF-axis for cancer therapy: development and validation of an IGF-trap as a potential drug

YM Chen, S Qi, S Perrino, M Hashimoto, P Brodt - Cells, 2020 - mdpi.com
The insulin-like growth factor (IGF)-axis was implicated in cancer progression and identified
as a clinically important therapeutic target. Several IGF-I receptor (IGF-IR) targeting drugs …

Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease

TU Ahearn, S Peisch, A Pettersson, EM Ebot… - …, 2018 - academic.oup.com
Circulating insulin-like growth factor-1 (IGF-1) is consistently associated with prostate cancer
risk. IGF-1 binds to IGF-1 receptor (IGF1R) and insulin receptor (IR), activating cancer …

Simvastatin ameliorates testosterone-induced prostatic hyperplasia in rats via modulating IGF-1/PI3K/AKT/FOXO signaling

NH El-Shafei, MA Zaafan, EA Kandil… - European journal of …, 2023 - Elsevier
Benign prostatic hyperplasia (BPH) is characterized by non-malignant enlargement of
prostate cells causing many lower urinary tract symptoms. BPH pathogenesis includes …

Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC‐3 cells

S Qian, H Fang, L Zheng, M Liu - Journal of Biochemical and …, 2021 - Wiley Online Library
Prostate cancer (PCa) is both the foremost and second cause of cancer death in the male
population. Patients with hormone‐dependent PCa are initially sensitive to androgen …

Sub-zeptomole detection of biomarker proteins using a microfluidic immunoarray with nanostructured sensors

L Dhanapala, AL Jones, P Czarnecki… - Analytical …, 2020 - ACS Publications
We report here a low-cost electrochemical immunoarray with unprecedented sensitivity in
the sub-zeptomole range with up to 5 log-decades dynamic range for accurate, multiplexed …

[PDF][PDF] Critical evaluation of transcripts and long noncoding RNA expression levels in prostate cancer following radical prostatectomy

C Ruiz, I Alborelli, M Manzo, B Calgua, EB Keller… - Pathobiology, 2023 - karger.com
Introduction: The clinical course of prostate cancer (PCa) is highly variable, ranging from
indolent behavior to rapid metastatic progression. The Gleason score is widely accepted as …

[HTML][HTML] The multifaceted role of extracellular vesicles in prostate cancer-a review

DP Jain, YH Dinakar, H Kumar, R Jain… - Cancer Drug …, 2023 - ncbi.nlm.nih.gov
Prostate cancer is the second most prominent form of cancer in men and confers the highest
mortality after lung cancer. The term “extracellular vesicles” refers to minute endosomal …

Updates on molecular and biochemical development and progression of prostate cancer

O Fahmy, NA Alhakamy, WY Rizg, A Bagalagel… - Journal of clinical …, 2021 - mdpi.com
Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in
men worldwide and occupies a very wide area of preclinical and clinical research. Targeted …

The role of insulin-like growth factors in the development of prostate cancer

JMP Holly, K Biernacka, CM Perks - Expert Review of …, 2020 - Taylor & Francis
Introduction Preclinical, clinical, and population studies have provided robust evidence for
an important role for the insulin-like growth factor (IGF) system in the development of …