The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

Development of the metanephric kidney is strongly dependent on complex signaling
pathways and cell–cell communication between at least four major progenitor cell …

Renal cyst development and expansion in autosomal dominant polycystic kidney disease
(ADPKD) involves both fluid secretion and abnormal proliferation of cyst-lining epithelial …

Background Rare autopsy studies have described smaller kidneys as well as urinary tract
anomalies in Down syndrome. This observation has never been investigated in vivo and …

The kidney vasculature is critical for renal function, but its developmental assembly
mechanisms remain poorly understood and models for studying its assembly dynamics are …

The kidney vasculature has a unique and complex architecture that is central for the kidney
to exert its multiple and essential physiological functions with the ultimate goal of …

The kidney is among the best characterized developing tissues, with the genes and
signaling pathways that regulate embryonic and adult kidney patterning and development …

The mammalian metanephric kidney is composed of two epithelial components, the
collecting duct system and the nephron epithelium, that differentiate from two different …

The tight regulation of vascular endothelial growth factor-A (VEGF-A) signaling is required
for both the development and maintenance of the glomerular filtration barrier, but the …

Chronic alveolar hypoxia, whether due to residence at high altitude or lung disease, leads to
a sustained increase in pulmonary vascular resistance and pulmonary hypertension (PH) …