The vascular endothelium is composed of a monolayer of specialized cells (endothelial
cells), which form the interface between the underlying smooth muscle cells from the …

The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Biomimetic drug delivery system offers new opportunities to mimic the biological
particulates, including cells, vesicles and viruses for enhancing biocompatibility and …

Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy,
and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal …

In primary prevention, regular physical activity decreases the incidence of cardiovascular
disease. At the endothelial level, this decreased incidence was attributed to higher …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

Objective: The aim was to clarify how smoking and nicotine affects wound healing processes
and to establish if smoking cessation and nicotine replacement therapy reverse the …

Cardiac hypertrophy is an adaptive response to physiological and pathological overload. In
response to the overload, individual cardiac myocytes become mechanically stretched and …

Ischemic stroke is a leading cause of death worldwide. A key secondary cell death
mechanism mediating neurological damage following the initial episode of ischemic stroke …