Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
Glucose transporters at the blood-brain barrier: function, regulation and gateways for drug delivery
SG Patching - Molecular neurobiology, 2017 - Springer
Glucose transporters (GLUTs) at the blood-brain barrier maintain the continuous high
glucose and energy demands of the brain. They also act as therapeutic targets and provide …
glucose and energy demands of the brain. They also act as therapeutic targets and provide …
[HTML][HTML] Self-organizing 3D human neural tissue derived from induced pluripotent stem cells recapitulate Alzheimer's disease phenotypes
The dismal success rate of clinical trials for Alzheimer's disease (AD) motivates us to
develop model systems of AD pathology that have higher predictive validity. The advent of …
develop model systems of AD pathology that have higher predictive validity. The advent of …
[HTML][HTML] Distinct contributions of astrocytes and pericytes to neuroinflammation identified in a 3D human blood-brain barrier on a chip
Neurovascular inflammation is a major contributor to many neurological disorders, but
modeling these processes in vitro has proven to be difficult. Here, we microengineered a …
modeling these processes in vitro has proven to be difficult. Here, we microengineered a …
Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
R Booth, H Kim - Lab on a Chip, 2012 - pubs.rsc.org
The blood-brain barrier (BBB), a unique selective barrier for the central nervous system
(CNS), hinders the passage of most compounds to the CNS, complicating drug …
(CNS), hinders the passage of most compounds to the CNS, complicating drug …
Nanoparticles for drug delivery: the need for precision in reporting particle size parameters
M Gaumet, A Vargas, R Gurny, F Delie - European journal of …, 2008 - Elsevier
Polymeric drug-loaded nanoparticles have been extensively studied in the field of drug
delivery. Biodistribution depends on the physicochemical properties of particles, especially …
delivery. Biodistribution depends on the physicochemical properties of particles, especially …
[HTML][HTML] In vitro modeling of the neurovascular unit: advances in the field
The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its
functional and structural integrity is vital in maintaining the homeostasis of the brain …
functional and structural integrity is vital in maintaining the homeostasis of the brain …
SyM-BBB: a microfluidic blood brain barrier model
B Prabhakarpandian, MC Shen, JB Nichols, IR Mills… - Lab on a Chip, 2013 - pubs.rsc.org
Current techniques for mimicking the Blood–Brain Barrier (BBB) largely use incubation
chambers (Transwell) separated with a filter and matrix coating to represent and to study …
chambers (Transwell) separated with a filter and matrix coating to represent and to study …
Inflammatory cell trafficking across the blood–brain barrier: chemokine regulation and in vitro models
Y Takeshita, RM Ransohoff - Immunological reviews, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is the brain‐specific capillary barrier that is critical for
preventing toxic substances from entering the central nervous system (CNS). In contrast to …
preventing toxic substances from entering the central nervous system (CNS). In contrast to …
Transcytosis: crossing cellular barriers
PL Tuma, AL Hubbard - Physiological reviews, 2003 - journals.physiology.org
Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …