Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA
repair pathway of clinical interest due to the sensitivity of homologous recombination …

Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …

Large-scale genomic studies have shown that half of epithelial ovarian cancers (EOCs)
have alterations in genes regulating homologous recombination (HR) repair. Loss of HR …

Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …

To ensure the high-fidelity transmission of genetic information, cells have evolved
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …

Maintenance of genome stability is essential for avoiding the passage to neoplasia. The
DNA-damage response—a cornerstone of genome stability—occurs by a swift transduction …

DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide
variety of genetic alterations including large-or small-scale deletions, loss of heterozygosity …

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …

The genomes of eukaryotic cells are under continuous assault by environmental agents (eg,
UV light and reactive chemicals) as well as the byproducts of normal intracellular …

Deficiency in either of the breast cancer susceptibility proteins BRCA1 or BRCA2 induces
profound cellular sensitivity to the inhibition of poly (ADP-ribose) polymerase (PARP) …