Liver fibrosis: mechanistic concepts and therapeutic perspectives

N Roehlen, E Crouchet, TF Baumert - Cells, 2020 - mdpi.com
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Silymarin/silybin and chronic liver disease: a marriage of many years

A Federico, M Dallio, C Loguercio - Molecules, 2017 - mdpi.com
Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound
is silybin, which has a remarkable biological effect. It is used in different liver disorders …

[HTML][HTML] Hepatoprotective effect of silymarin

N Vargas-Mendoza, E Madrigal-Santillán… - World journal of …, 2014 - ncbi.nlm.nih.gov
The use of medicinal plants in treating illnesses has been reported since ancestral times. In
the case of hepatic diseases, several species such as Silybum marianum, Phyllanthus niruri …

Milk thistle in liver diseases: past, present, future

L Abenavoli, R Capasso, N Milic… - Phytotherapy …, 2010 - Wiley Online Library
Silybum marianum or milk thistle (MT) is the most well‐researched plant in the treatment of
liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and …

The use of silymarin in the treatment of liver diseases

R Saller, R Meier, R Brignoli - Drugs, 2001 - Springer
The high prevalence of liver diseases such as chronic hepatitis and cirrhosis underscores
the need for efficient and cost-effective treatments. The potential benefit of silymarin …

Oxidative stress-related molecules and liver fibrosis

M Parola, G Robino - Journal of hepatology, 2001 - Elsevier
Liver fibrosis can be considered as a dynamic and highly integrated cellular response to
chronic liver injury [1]. Whatever the etiology, the evolution of chronic liver disease (CLD) is …

Cutaneous photodamage, oxidative stress, and topical antioxidant protection

SR Pinnell - Journal of the American Academy of Dermatology, 2003 - Elsevier
New methods to protect skin from photodamage from sun exposure are necessary if we are
to conquer skin cancer and photoaging. Sunscreens are useful, but their protection is not …

[PDF][PDF] A review of plants used in the treatment of liver disease: part 1

ND Scott Luper - Alternative medicine review, 1998 - anaturalhealingcenter.com
Botanicals have been used traditionally by herbalists and indigenous healers worldwide for
the prevention and treatment of liver disease. Clinical research in this century has confirmed …

Pharmacology of silymarin

F Fraschini, G Demartini, D Esposti - Clinical drug investigation, 2002 - Springer
The flavonoid silymarin and one of its structural components, silibinin, are substances with
documented hepatoprotective properties. Their mechanisms of action are still poorly …

Redox mechanisms in hepatic chronic wound healing and fibrogenesis

E Novo, M Parola - Fibrogenesis & tissue repair, 2008 - Springer
Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue
environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have …