Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Frailty is a functional status that precedes disability and is characterized by decreased
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-
dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular …

Insulin-producing β-cells in pancreatic islets are regulated by systemic cues and, locally, by
adjacent islet hormone-producing 'non-β-cells'(namely α-cells, δ-cells and γ-cells). Yet …

Epigenetics is the study of heritable mechanisms that can modify gene activity and
phenotype without modifying the genetic code. The basis for the concept of epigenetics …