Cleavage of HDAC6 to dampen its antiviral activity by nsp5 is a common strategy of swine enteric coronaviruses
ABSTRACT HDAC6, a structurally and functionally unique member of the histone
deacetylase (HDAC) family, is an important host factor that restricts viral infection. The broad …
deacetylase (HDAC) family, is an important host factor that restricts viral infection. The broad …
Hyperacetylated microtubules assist porcine deltacoronavirus nsp8 to degrade MDA5 via SQSTM1/p62-dependent selective autophagy
Z Li, Y Lai, R Qiu, W Tang, J Ren, S Xiao… - Journal of …, 2024 - Am Soc Microbiol
The microtubule (MT) is a highly dynamic polymer that functions in various cellular
processes through MT hyperacetylation. Thus, many viruses have evolved mechanisms to …
processes through MT hyperacetylation. Thus, many viruses have evolved mechanisms to …
Siah2-and LRSAM1-mediated K63-linked ubiquitination of snakehead vesiculovirus nucleoprotein facilitates viral replication
N Jiang, H Zhao, X Qin, YA Zhang, J Tu - Journal of Virology, 2024 - Am Soc Microbiol
Nucleoprotein (N) is well known for its function in the encapsidation of the genomic RNAs of
negative-strand RNA viruses, which leads to the formation of ribonucleoproteins that serve …
negative-strand RNA viruses, which leads to the formation of ribonucleoproteins that serve …
Recombinant porcine interferon δ8 inhibited porcine deltacoronavirus infection in vitro and in vivo
J Yao, Z Yang, X Guo, J Wang, B Yu, S Liu, X Hu… - International Journal of …, 2024 - Elsevier
Porcine deltacoronavirus (PDCoV) poses a significant threat to both the pig industry and
public safety, and has recently been identified in humans. Currently, there are no …
public safety, and has recently been identified in humans. Currently, there are no …
[HTML][HTML] Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets
D Lin, W Lai, N Zheng, H Luo, X Chen, W Que… - Frontiers in …, 2024 - frontiersin.org
Objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease. Its pathogenesis
has not yet been clarified, so it is urgent to explore therapeutic targets. Here, we clarified the …
has not yet been clarified, so it is urgent to explore therapeutic targets. Here, we clarified the …