Background Oocyte growth is accompanied by follicular development in mammalian
ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 …

The development of germ cells relies on contact and communication with neighboring
somatic cells that provide metabolic support and regulatory signals. In females, contact is …

STUDY QUESTION How does biochemical stimulation or inhibition of the PI3K/Akt/mTOR
pathway affect the activation and the growth of human primordial follicles in vitro …

Purpose Mammalian oogenesis and folliculogenesis share a dynamic connection that is
critical for gamete development. For maintenance of quiescence or follicular activation …

Prior to ovulation, the mammalian oocyte undergoes a process of differentiation within the
ovarian follicle that confers on it the ability to give rise to an embryo. Differentiation …

In mammalian ovaries, immature oocytes are reserved in primordial follicles until their
activation for potential ovulation. Precise control of primordial follicle activation (PFA) is …

Primordial follicles are the starting point of follicular development and the basic functional
unit of female reproduction. Primordial follicles are formed around birth, and most of the …

Müllerian inhibiting substance (MIS/AMH), produced by granulosa cells of growing follicles,
is an important regulator of folliculogenesis and follicle development. Treatment with …

In recent years, ovarian tissue cryopreservation has rapidly developed as a successful
method for preserving the fertility of girls and young women with cancer or benign conditions …

In fetal females, oogonia proliferate immediately after sex determination. The progress of
mitosis in oogonia proceeds so rapidly that the incompletely divided cytoplasm of the sister …