Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows

G Esposito, PC Irons, EC Webb… - Animal reproduction …, 2014 - Elsevier
The biological cycles of milk production and reproduction determine dairying profitability
thus making management decisions dynamic and time-dependent. Diseases also negatively …

A review of the ongoing discussion about definition, diagnosis and pathomechanism of subclinical endometritis in dairy cows

K Wagener, C Gabler, M Drillich - Theriogenology, 2017 - Elsevier
In the last decade, several new aspects of the inflammation of the bovine endometrium have
been investigated and described, including a new definition of subclinical endometritis. This …

Innate immunity and inflammation of the bovine female reproductive tract in health and disease

IM Sheldon, JG Cronin, GD Healey, C Gabler… - …, 2014 - rep.bioscientifica.com
In mammals, the sperm activates the development of the egg by triggering a series of
oscillations in the cytosolic-free Ca 2+ concentration (Ca 2+ i). The sperm triggers these …

Delayed differentiation of vaginal and uterine microbiomes in dairy cows developing postpartum endometritis

R Miranda-CasoLuengo, J Lu, EJ Williams… - PloS one, 2019 - journals.plos.org
Bacterial overgrowth in the uterus is a normal event after parturition. In contrast to the
healthy cow, animals unable to control the infection within 21 days after calving develop …

Micronutrient programming of development throughout gestation

CJ Ashworth, C Antipatis - Reproduction, 2001 - rep.bioscientifica.com
Vitamins and minerals serve essential roles in cellular metabolism, maintenance and growth
throughout life. They are also central components of many enzymes and transcription …

Bidirectional psychoneuroimmune interactions in the early postpartum period influence risk of postpartum depression

EJ Corwin, K Pajer, S Paul, N Lowe, M Weber… - Brain, behavior, and …, 2015 - Elsevier
More than 500,000 US women develop postpartum depression (PPD) annually. Although
psychosocial risks are known, the underlying biology remains unclear. Dysregulation of the …

Cervico-vaginal mucus (CVM)–an accessible source of immunologically informative biomolecules

M Adnane, KG Meade, C O'Farrelly - Veterinary research communications, 2018 - Springer
Abstract Cervico-vaginal mucus (CVM), the product of epithelial cells lining the uterus, cervix
and vagina, is secreted to facilitate uterine lubrication and microbial clearance …

Bovine β-defensin gene family: opportunities to improve animal health?

KG Meade, P Cormican, F Narciandi… - Physiological …, 2014 - journals.physiology.org
Recent analysis of the bovine genome revealed an expanded suite of β-defensin genes that
encode what are referred to as antimicrobial or host defense peptides (HDPs). Whereas …

[HTML][HTML] Invited review: Risk factors for transition period disease in intensive grazing and housed dairy cattle

RR Daros, DM Weary, MAG von Keyserlingk - Journal of Dairy Science, 2022 - Elsevier
Transition period (±3 wk around calving) diseases are prevalent in dairy systems. In this
review we describe the physiological and behavioral changes experienced by cows during …

Non-canonical inflammasome-mediated IL-1β production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent

P Kelly, KG Meade, C O'Farrelly - Frontiers in Immunology, 2019 - frontiersin.org
Inflammation of the post-partum uterus is a normal physiological event, crucial for tissue
involution and repair. However, in the bovine, some cows fail to resolve this inflammation …