For decades, nanomedicines have been reported as a potential means to overcome the
limitations of conventional drug delivery systems by reducing side effects, toxicity and the …

Introduction: Glaucoma is a multifactorial disease characterized by progressive optic nerve
injury and visual field defects. Elevated intraocular pressure (IOP) is the most widely …

Purpose To investigate the intra‐ocular pressure (IOP)‐lowering effects of a selective Rho
kinase inhibitor, ripasudil (K‐115), over 24 hr in patients with primary open‐angle glaucoma …

Importance We conducted a series of phase 1 clinical trials to elucidate the efficacy and
safety of the selective Rho kinase inhibitor K-115 as a candidate drug for the treatment of …

Abnormally high resistance to aqueous humor drainage via the trabecular meshwork and
Schlemm's canal is highly correlated with the development of primary open-angle glaucoma …

The elevated intraocular pressure (IOP) of primary open-angle glaucoma is caused by
impaired outflow of aqueous humor through the trabecular meshwork. Within the …

Introduction: Ocular hypertension in open-angle glaucoma is caused by a reduced rate of
removal of aqueous humour (AH) from the eye, with the majority of AH draining from the …

Marine-derived macrolides latrunculins A and B, of the Red Sea sponge Negombata
magnifica, are the first marine natural products that have been found to reversibly bind to …

purpose. To determine the effect of the F-actin-disrupting agent latrunculin-B on aqueous
outflow facility and trabecular meshwork architecture in human eyes. methods. After …

The marine-derived macrolides latrunculins A (1) and B, from the Red Sea sponge
Negombata magnifica, have been found to reversibly bind actin monomers, forming a 1: 1 …