Enantiomeric separation is a key step in the development of a new chiral drug. Preparative
liquid chromatography (LC) continues to be the technique of choice either during the drug …

The glucagon-like peptide 1 (Glp-1) has emerged as a hormone with broad pharmacological
potential in type 2 diabetes (T2D) treatment, notably by improving β cell functions. The cell …

In this project, a novel magnetic nano catalyst was used in solvent-free conditions in three
different experimental fabrication sections, including the synthesis of hexahydroquinolines, 5 …

Neurotrauma is among the main causes of human disability and mortality. The transcription
factor E2F1 is one of the key proteins that determine the fate of cells. The involvement of …

Chiral hydantoins display potential antidepressant and anticancer activities. The quantitative
structure property relationship (QSPR) study on chiral compounds plays a key role in …

A thionation reaction was performed on some chiral flavanones using Lawesson's reagent
(LR) and leads to the formation of new chiral thiocarbonyl flavanes. LR in this thionation …

The combination of two tools of the green and sustainable organic synthesis,
multicomponent reactions and microwave irradiation, makes it possible to generate diverse …

The loss of pancreatic β-cell identity has emerged as an important feature of type 2 diabetes
development, but the molecular mechanisms are still elusive. Here, we explore the cell …

Aberrant activation of the Hedgehog (Hh) signaling pathway has been observed in various
human malignancies. Glioma-associated oncogene transcription factor 1 (GLI1) is the …

Volume 1 of this book has a chapter about fundamentals of enantioselective liquid
chromatography. This chapter discusses the analytical and preparative-scale applications of …