Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine
thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

The discovery that a subset of human tumours is dependent on mutationally deregulated
BRAF kinase intensified the development of RAF inhibitors to be used as potential …

The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …

The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein
synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream …

Many human malignancies are associated with aberrant regulation of protein or lipid
kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein …

Tumours with mutant BRAF are dependent on the RAF–MEK–ERK signalling pathway for
their growth,,. We found that ATP-competitive RAF inhibitors inhibit ERK signalling in cells …

Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours
and 40% of melanoma, respectively, thus targeting this pathway could have broad …

The discovery and development of small molecule cancer drugs has been revolutionised
over the last decade. Most notably, we have moved from a one-size-fits-all approach that …

The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG
and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K …