[HTML][HTML] In vitro activation early follicles: from the basic science to the clinical perspectives

KCT Vo, K Kawamura - International Journal of Molecular Sciences, 2021 - mdpi.com
Development of early follicles, especially the activation of primordial follicles, is strictly
modulated by a network of signaling pathways. Recent advance in ovarian physiology has …

Single-cell sequencing reveals suppressive transcriptional programs regulated by MIS/AMH in neonatal ovaries

MC Meinsohn, HD Saatcioglu, L Wei… - Proceedings of the …, 2021 - National Acad Sciences
Müllerian inhibiting substance (MIS/AMH), produced by granulosa cells of growing follicles,
is an important regulator of folliculogenesis and follicle development. Treatment with …

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve

CHK Hughes, OE Smith… - Proceedings of the …, 2023 - National Acad Sciences
The ovarian follicle reserve, formed pre-or perinatally, comprises all oocytes for lifetime
reproduction. Depletion of this reserve results in infertility. Steroidogenic factor 1 (SF-1; …

A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives

Y Li, L Wei, MC Meinsohn, R Suliman… - Proceedings of the …, 2022 - National Acad Sciences
We identified the anti-Mullerian hormone (also known as Müllerian inhibiting substance or
MIS) as an inhibitory hormone that induces long-term contraception in mammals. The type II …

FOXL2 interaction with different binding partners regulates the dynamics of ovarian development

R Migale, M Neumann, R Mitter, MR Rafiee… - Science …, 2024 - science.org
The transcription factor FOXL2 is required in ovarian somatic cells for female fertility.
Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to …

The role of steroidogenic factor 1 (SF-1) in steroidogenic cell function of the testes and ovaries of mature mice

OE Smith, F Morin, V Roussel, MC Bertucci… - …, 2023 - rep.bioscientifica.com
In brief The nuclear receptor steroidogenic factor 1 (SF-1) is essential for mature mouse
gonad steroidogenic gene expression, for Leydig and Sertoli cell function, and depletion of …

Genomics of sexual cell fate transdifferentiation in the mouse gonad

MW Murphy, MD Gearhart, A Wheeler, VJ Bardwell… - G3, 2022 - academic.oup.com
Sex determination in mammals hinges on a cell fate decision in the fetal bipotential gonad
between formation of male Sertoli cells or female granulosa cells. While this decision …

[HTML][HTML] Loss of ERβ Disrupts Gene Regulation in Primordial and Primary Follicles

EB Lee, VP Chakravarthi, R Mohamadi… - International Journal of …, 2024 - mdpi.com
Loss of ERβ increases primordial follicle growth activation (PFGA), leading to premature
ovarian follicle reserve depletion. We determined the expression and gene regulatory …

[HTML][HTML] Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis

KS Agrimson, A Minkina, D Sadowski, A Wheeler… - PLoS …, 2022 - journals.plos.org
The mammalian nuclear hormone receptors LRH1 (NR5A2) and SF1 (NR5A1) are close
paralogs that can bind the same DNA motif and play crucial roles in gonadal development …

miR-27a-3p targets NR5A2 to regulate CYP19A1 expression and 17-β estradiol synthesis in ovine granulosa cells

H Gui, F Li, C Chen, Q Zhu, C Zhang, J Zhang… - Animal Reproduction …, 2023 - Elsevier
Abstract Although 17-β estradiol (E2) synthesis is important in regulating female fertility, we
know little regarding the molecular mechanism of miRNA-regulated ovine E2 synthesis …