Development of early follicles, especially the activation of primordial follicles, is strictly
modulated by a network of signaling pathways. Recent advance in ovarian physiology has …

Müllerian inhibiting substance (MIS/AMH), produced by granulosa cells of growing follicles,
is an important regulator of folliculogenesis and follicle development. Treatment with …

The ovarian follicle reserve, formed pre-or perinatally, comprises all oocytes for lifetime
reproduction. Depletion of this reserve results in infertility. Steroidogenic factor 1 (SF-1; …

We identified the anti-Mullerian hormone (also known as Müllerian inhibiting substance or
MIS) as an inhibitory hormone that induces long-term contraception in mammals. The type II …

The transcription factor FOXL2 is required in ovarian somatic cells for female fertility.
Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to …

In brief The nuclear receptor steroidogenic factor 1 (SF-1) is essential for mature mouse
gonad steroidogenic gene expression, for Leydig and Sertoli cell function, and depletion of …

Sex determination in mammals hinges on a cell fate decision in the fetal bipotential gonad
between formation of male Sertoli cells or female granulosa cells. While this decision …

Loss of ERβ increases primordial follicle growth activation (PFGA), leading to premature
ovarian follicle reserve depletion. We determined the expression and gene regulatory …

The mammalian nuclear hormone receptors LRH1 (NR5A2) and SF1 (NR5A1) are close
paralogs that can bind the same DNA motif and play crucial roles in gonadal development …

Abstract Although 17-β estradiol (E2) synthesis is important in regulating female fertility, we
know little regarding the molecular mechanism of miRNA-regulated ovine E2 synthesis …