Synthesis of indazole motifs and their medicinal importance: An overview
DD Gaikwad, AD Chapolikar, CG Devkate… - European journal of …, 2015 - Elsevier
Indazoles is an important class of heterocyclic compounds having a wide range of biological
and pharmaceutical applications. There is enormous potential in the synthesis of novel …
and pharmaceutical applications. There is enormous potential in the synthesis of novel …
A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective
S Mal, U Malik, M Mahapatra, A Mishra… - Drug Development …, 2022 - Wiley Online Library
With different nitrogen‐containing heterocyclic moieties, Indazoles earn one of the places
among the top investigated molecules in medicinal research. Indazole, an important fused …
among the top investigated molecules in medicinal research. Indazole, an important fused …
Indazole: A medicinally important heterocyclic moiety
A Thangadurai, M Minu, S Wakode, S Agrawal… - Medicinal Chemistry …, 2012 - Springer
This article reveals the various biological activities of the heterocyclic compound, indazole,
including anti-inflammatory, antimicrobial, antiHIV, anticancer, hypoglycemic, antiprotozoal …
including anti-inflammatory, antimicrobial, antiHIV, anticancer, hypoglycemic, antiprotozoal …
Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?
M Boiani, L Piacenza, P Hernandez, L Boiani… - Biochemical …, 2010 - Elsevier
Chagas disease is caused by the trypanosomatid parasite Trypanosoma cruzi and threatens
millions of lives in South America. As other neglected diseases there is almost no research …
millions of lives in South America. As other neglected diseases there is almost no research …
Exploring Synthetic Strategies for 1H‐Indazoles and Their N‐Oxides: Electrochemical Synthesis of 1H‐Indazole N‐Oxides and Their Divergent C−H …
The selective electrochemical synthesis of 1H‐indazoles and their N‐oxides and the
subsequent C− H functionalization of the 1H‐indazole N‐oxides are described. The …
subsequent C− H functionalization of the 1H‐indazole N‐oxides are described. The …
Rh (III)-Catalyzed C–H Functionalization/Annulation of 1-Arylindazolones: Divergent Synthesis of Fused Indazolones and Allyl Indazolones
B Shu, JL Song, SY Chen, YC Zheng… - The Journal of Organic …, 2023 - ACS Publications
Rh (III)-catalyzed C–H/N–H annulation and C–H allylation of phenylindazolones have been
realized by employing 5-methylene-1, 3-dioxan-2-one and 4-vinyl-1, 3-dioxolan-2-one as …
realized by employing 5-methylene-1, 3-dioxan-2-one and 4-vinyl-1, 3-dioxolan-2-one as …
Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
Indazole-based Schiff base analogues (1–27) were synthesized by a three-step reaction
pathway starting from 1-methyl-1H-indazole-3-carboxylic acid as the basic compound. The …
pathway starting from 1-methyl-1H-indazole-3-carboxylic acid as the basic compound. The …
[HTML][HTML] In vitro activity and mechanism of cell death induction of cyanomethyl vinyl ethers derivatives against Trypanosoma cruzi
CJ Bethencourt-Estrella, S Delgado-Hernández… - International Journal for …, 2023 - Elsevier
Chagas disease causes a problematic pathology that can lead to megacolon and heart
disease, and can even cause the death of the patient. Current therapies for this disease are …
disease, and can even cause the death of the patient. Current therapies for this disease are …
Palladium-catalyzed oxidative C–H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones
Y Wu, LJ Feng, X Lu, FY Kwong, HB Luo - Chemical Communications, 2014 - pubs.rsc.org
A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives
for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in …
for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in …
Imidazolidines as new anti-Trypanosoma cruzi agents: Biological evaluation and structure–activity relationships
MC Caterina, IA Perillo, L Boiani, H Pezaroglo… - Bioorganic & medicinal …, 2008 - Elsevier
Imidazolidine derivatives were studied as anti-Trypanosoma cruzi agents. Imidazolines can
be considered as ethylenediamine/carbonyl precursors and therefore interfere with the …
be considered as ethylenediamine/carbonyl precursors and therefore interfere with the …