[PDF][PDF] Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular Plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

Review of recent developments in GC–MS approaches to metabolomics-based research

DJ Beale, FR Pinu, KA Kouremenos, MM Poojary… - Metabolomics, 2018 - Springer
Background Metabolomics aims to identify the changes in endogenous metabolites of
biological systems in response to intrinsic and extrinsic factors. This is accomplished …

[HTML][HTML] Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

P Sen, S Qadri, PK Luukkonen, O Ragnarsdottir… - Journal of …, 2022 - Elsevier
Background & aims Recent experimental models and epidemiological studies suggest that
specific environmental contaminants (ECs) contribute to the initiation and pathology of non …

Human gut microbes impact host serum metabolome and insulin sensitivity

HK Pedersen, V Gudmundsdottir, HB Nielsen… - Nature, 2016 - nature.com
Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …

Metabolomics: beyond biomarkers and towards mechanisms

CH Johnson, J Ivanisevic, G Siuzdak - Nature reviews Molecular cell …, 2016 - nature.com
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

A metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable Nutrition Facts panels

S van Vliet, JR Bain, MJ Muehlbauer, FD Provenza… - Scientific reports, 2021 - nature.com
A new generation of plant-based meat alternatives—formulated to mimic the taste and
nutritional composition of red meat—have attracted considerable consumer interest …

Metabolomics by gas chromatography–mass spectrometry: Combined targeted and untargeted profiling

O Fiehn - Current protocols in molecular biology, 2016 - Wiley Online Library
Gas chromatography–mass spectrometry (GC‐MS)–based metabolomics is ideal for
identifying and quantitating small‐molecule metabolites (< 650 Da), including small acids …

ChEBI in 2016: Improved services and an expanding collection of metabolites

J Hastings, G Owen, A Dekker, M Ennis… - Nucleic acids …, 2016 - academic.oup.com
ChEBI is a database and ontology containing information about chemical entities of
biological interest. It currently includes over 46 000 entries, each of which is classified within …

DrugBank 4.0: shedding new light on drug metabolism

V Law, C Knox, Y Djoumbou, T Jewison… - Nucleic acids …, 2014 - academic.oup.com
Abstract DrugBank (http://www. drugbank. ca) is a comprehensive online database
containing extensive biochemical and pharmacological information about drugs, their …

Mass spectral databases for LC/MS-and GC/MS-based metabolomics: State of the field and future prospects

M Vinaixa, EL Schymanski, S Neumann… - TrAC Trends in …, 2016 - Elsevier
At present, mass spectrometry (MS)-based metabolomics has been widely used to obtain
new insights into human, plant, and microbial biochemistry; drug and biomarker discovery; …