Exploring the next generation of antibody–drug conjugates

K Tsuchikama, Y Anami, SYY Ha… - Nature Reviews Clinical …, 2024 - nature.com
Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …

[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing

F Ahmed, A Samantasinghar, AM Soomro, S Kim… - Journal of Biomedical …, 2023 - Elsevier
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …

ADCdb: the database of antibody–drug conjugates

L Shen, X Sun, Z Chen, Y Guo, Z Shen… - Nucleic Acids …, 2024 - academic.oup.com
Antibody-drug conjugates (ADCs) are a class of innovative biopharmaceutical drugs, which,
via their antibody (mAb) component, deliver and release their potent warhead (aka. payload) …

[HTML][HTML] A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy

F Riccardi, M Dal Bo, P Macor, G Toffoli - Frontiers in Pharmacology, 2023 - frontiersin.org
Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer
compounds that are widely used in the treatment of hematologic malignancies and solid …

[HTML][HTML] Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

N Sunildutt, P Parihar… - Frontiers in …, 2023 - frontiersin.org
The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …

Novel formats of antibody conjugates: recent advances in payload diversity, conjugation, and linker chemistry

T Fujii, Y Matsuda - Expert Opinion on Biological Therapy, 2023 - Taylor & Francis
Introduction In the field of bioconjugates, the focus on antibody–drug conjugates (ADCs)
with novel payloads beyond the traditional categories of potent cytotoxic agents is …

[HTML][HTML] Antibody-drug conjugates for breast cancer treatment: emerging agents, targets and future directions

T Yang, W Li, T Huang, J Zhou - International Journal of Molecular …, 2023 - mdpi.com
To achieve the scheme of “magic bullets” in antitumor therapy, antibody-drug conjugates
(ADCs) were developed. ADCs consist of antibodies targeting tumor-specific antigens …

[HTML][HTML] Network-based drug repurposing for HPV-associated cervical cancer

F Ahmed, YJ Yang, A Samantasinghar, YW Kim… - Computational and …, 2023 - Elsevier
In women, cervical cancer (CC) is the fourth most common cancer around the world with
average cases of 604,000 and 342,000 deaths per year. Approximately 50% of high-grade …

Network-based drug repurposing identifies small molecule drugs as immune checkpoint inhibitors for endometrial cancer

F Ahmed, A Samantasinghar, W Ali, KH Choi - Molecular Diversity, 2024 - Springer
Endometrial cancer (EC) is the 6th most common cancer in women around the world. Alone
in the United States (US), 66,200 new cases and 13,030 deaths are expected to occur in …

[HTML][HTML] Standardizing digital biobanks: integrating imaging, genomic, and clinical data for precision medicine

V Brancato, G Esposito, L Coppola, C Cavaliere… - Journal of Translational …, 2024 - Springer
Advancements in data acquisition and computational methods are generating a large
amount of heterogeneous biomedical data from diagnostic domains such as clinical …