Appropriate levels of phosphate in the body are maintained by the coordinated regulation of
the bone-derived growth factor FGF23 and the membrane-bound protein Klotho. The …

T he retractile and remodeling phenomena accompanying and, in pathologic situations,
following the healing of an open wound have attracted the interest of physicians and …

A major breakthrough in systemic phosphate homeostasis regulation was achieved by the
demonstration of strikingly similar physical, morphological, and biochemical phenotypes of …

Abstract The Predictive Safety Testing Consortium's first regulatory submission to qualify
kidney safety biomarkers revealed two deficiencies. To address the need for biomarkers that …

Activated signaling cascades in the proximal tubular cells of the kidneys play a crucial role in
the development of tubulointerstitial fibrosis. Inhibition of these signaling cascades with …

Understanding the physiological regulation of mineral ion metabolism is essential for
determining the pathomechanisms of skeletal, vascular, and renal diseases associated with …

Bone marrow–derived cells (BMDC) have been proposed to exert beneficial effects after
renal ischemia/reperfusion injury (IRI) by engraftment in the tubular epithelium. However …

Aims Several signaling events have been identified for mediating cisplatin-induced chronic
inflammation and progressive renal fibrosis, but the majority of them have not yet been …

Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that is required
for molecular maturation of various types of collagens. Recent studies have shown a close …

Activation of TGF-β/Smad signaling plays a central role in the pathogenesis of
tubulointerstitial fibrosis, but the mechanisms underlying the initial interaction of the TGF-β …