Fusion oncogenes (FOs) are common in many cancer types and are powerful drivers of
tumor development. Because their expression is exclusive to cancer cells and their …

Abstract PD-1/L1 and CTLA-4 blockade immunotherapies have been approved for 13 types
of cancers and are being studied in diffuse large B-cell lymphoma (DLBCL), the most …

The TINCR (T erminal differentiation-I nduced N on-C oding R NA) gene is selectively
expressed in epithelium tissues and is involved in the control of human epidermal …

Chromosomal translocations in cancer as well as benign neoplasias typically lead to the
formation of fusion genes. Such genes may encode chimeric proteins when two protein …

Non-homologous end-joining (NHEJ) is the preferred mechanism used by hematopoietic
stem cells (HSCs) to repair double-stranded DNA breaks and is particularly increased in …

Pheochromocytomas and paragangliomas are rare neuroendocrine tumours. Around 20-
25% of patients develop metastases, for which there is an urgent need of prognostic markers …

CD19-directed chimeric antigen receptor (CAR) T cells have yielded impressive response
rates in refractory/relapse B cell acute lymphoblastic leukemia (B-ALL); however, most …

Background Comprehensive molecular studies on tumours are needed to delineate
immortalization process steps and identify sensitive prognostic biomarkers in thyroid cancer …

To accurately recapitulate the heterogeneity of human diseases, animal models require to
recreate multiple complex genetic alterations. Here, we combine the RCAS-TVA system with …

Efficient methodologies for recreating cancer-associated chromosome translocations are in
high demand as tools for investigating how such events initiate cancer. The CRISPR/Cas9 …