Engaging innate immunity in HIV-1 cure strategies

NL Board, M Moskovljevic, F Wu, RF Siliciano… - Nature Reviews …, 2022 - nature.com
Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …

Curing HIV: seeking to target and clear persistent infection

DM Margolis, NM Archin, MS Cohen, JJ Eron, G Ferrari… - Cell, 2020 - cell.com
Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …

Latency reversal plus natural killer cells diminish HIV reservoir in vivo

JT Kim, TH Zhang, C Carmona, B Lee, CS Seet… - Nature …, 2022 - nature.com
HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …

The reservoir of latent HIV

J Chen, T Zhou, Y Zhang, S Luo, H Chen… - Frontiers in cellular …, 2022 - frontiersin.org
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …

Tissue-resident NK cells: development, maturation, and clinical relevance

E Hashemi, S Malarkannan - Cancers, 2020 - mdpi.com
Natural killer (NK) cells belong to type 1 innate lymphoid cells (ILC1) and are essential in
killing infected or transformed cells. NK cells mediate their effector functions using non …

NK cells in HIV-1 infection: from basic science to vaccine strategies

L Flórez-Álvarez, JC Hernandez, W Zapata - Frontiers in immunology, 2018 - frontiersin.org
NK cells play a key role in immune response against HIV infection. These cells can destroy
infected cells and contribute to adequate and strong adaptive immune responses, by acting …

Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs

I Sadowski, FB Hashemi - Cellular and Molecular Life Sciences, 2019 - Springer
Abstract 35 years since identification of HIV as the causative agent of AIDS, and 35 million
deaths associated with this disease, significant effort is now directed towards the …

Natural killer cells play an important role in virus infection control: Antiviral mechanism, subset expansion and clinical application

W Zuo, X Zhao - Clinical Immunology, 2021 - Elsevier
With the global spread of coronavirus disease 2019 (COVID-19), the important role of
natural killer (NK) cells in the control of various viral infections attracted more interest, via …

The cytokine/chemokine response in Leishmania/HIV infection and co-infection

S Maksoud, J El Hokayem - Heliyon, 2023 - cell.com
HIV infection progressively weakens the immune system by infecting and destroying cells
involved in host defense. Viral infection symptoms are generated and aggravated as …

[HTML][HTML] Immunological approaches to HIV cure

AR Ward, TM Mota, RB Jones - Seminars in immunology, 2021 - Elsevier
Combination antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV)
infection has proven remarkably successful–for those who can access and afford it–yet HIV …