Therapeutic targeting of “undruggable” MYC
V Llombart, MR Mansour - EBioMedicine, 2022 - thelancet.com
Summary c-MYC controls global gene expression and regulates cell proliferation, cell
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …
Targeting Pim kinases in hematological cancers: molecular and clinical review
M Bellon, C Nicot - Molecular Cancer, 2023 - Springer
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …
CancerGPT for few shot drug pair synergy prediction using large pretrained language models
Large language models (LLMs) have been shown to have significant potential in few-shot
learning across various fields, even with minimal training data. However, their ability to …
learning across various fields, even with minimal training data. However, their ability to …
Current methods of post-translational modification analysis and their applications in blood cancers
Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …
Comprehensive insights that targeting PIM for cancer therapy: prospects and obstacles
L Chen, W Mao, C Ren, J Li… - Journal of Medicinal …, 2024 - ACS Publications
Proviral integration sitea for Moloney-murine leukemia virus (PIM) kinases are a family of
highly conserved serine/tyrosine kinases consisting of three members, PIM-1, PIM-2, and …
highly conserved serine/tyrosine kinases consisting of three members, PIM-1, PIM-2, and …
Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models
Myelofibrosis (MF) is the deadliest form of myeloproliferative neoplasm (MPN). The JAK
inhibitor Ruxolitinib can reduce constitutional symptoms but it does not substantially improve …
inhibitor Ruxolitinib can reduce constitutional symptoms but it does not substantially improve …
[HTML][HTML] Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis
TX Pham, J Lee, J Guan, N Caporarello, JA Meridew… - JCI insight, 2022 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by
myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene …
myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene …
[HTML][HTML] PIM kinases regulate early human Th17 cell differentiation
T Buchacher, A Shetty, SA Koskela, J Smolander… - Cell Reports, 2023 - cell.com
The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (ie, PIM1,
PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are …
PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are …
Targeting PIM kinases to improve the efficacy of immunotherapy
AN Clements, NA Warfel - Cells, 2022 - mdpi.com
The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of
serine/threonine kinases that regulates numerous signaling networks that promote cell …
serine/threonine kinases that regulates numerous signaling networks that promote cell …
Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects
Background PIM kinases are well-studied drug targets for cancer, belonging to
Serine/Threonine kinases family. They are the downstream target of various signaling …
Serine/Threonine kinases family. They are the downstream target of various signaling …