Viral and host mediators of non-suppressible HIV-1 viremia
Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity
ABSTRACT A host cellular transmembrane protein, SERINC5, inhibits HIV-1 infectivity when
incorporated into progeny virions. Recent studies suggest that certain Envelope …
incorporated into progeny virions. Recent studies suggest that certain Envelope …
Inferring human immunodeficiency virus 1 proviral integration dates with Bayesian inference
Human immunodeficiency virus 1 (HIV) proviruses archived in the persistent reservoir
currently pose the greatest obstacle to HIV cure due to their evasion of combined …
currently pose the greatest obstacle to HIV cure due to their evasion of combined …
Differential Pressures of SERINC5 and IFITM3 on HIV-1 Envelope Glycoprotein over the Course of HIV-1 Infection
Infection of human immunodeficiency virus type 1 (HIV-1) is subject to restriction by cellular
factors. Serine incorporator 5 (SERINC5) and interferon-inducible transmembrane 3 …
factors. Serine incorporator 5 (SERINC5) and interferon-inducible transmembrane 3 …
Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen
The pathogenesis of HIV-1 infection is governed by a highly dynamic, time-dependent
interaction between the host and the viral genome. In this study, we developed a novel …
interaction between the host and the viral genome. In this study, we developed a novel …
Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals
HIV-1 Nef plays an essential role in enhancing virion infectivity by antagonizing the host
restriction molecule SERINC5. Because Nef is highly polymorphic due to the selective forces …
restriction molecule SERINC5. Because Nef is highly polymorphic due to the selective forces …
Nef obtained from individuals with HIV-1 vary in their ability to antagonize SERINC3-and SERINC5-mediated HIV-1 restriction
Z Kruize, AC van Nuenen, SW van Wijk, AF Girigorie… - Viruses, 2021 - mdpi.com
Nef is a multifunctional viral protein that has the ability to downregulate cell surface
molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as …
molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as …
Multiple haplotype reconstruction from allele frequency data
Because haplotype information is of widespread interest in biomedical applications, effort
has been put into their reconstruction. Here, we propose an efficient method, called …
has been put into their reconstruction. Here, we propose an efficient method, called …
Adaptation to HLA-associated immune pressure over the course of HIV infection and in circulating HIV-1 strains
Adaptation to human leukocyte antigen (HLA)-associated immune pressure represents a
major driver of human immunodeficiency virus (HIV) evolution at both the individual and …
major driver of human immunodeficiency virus (HIV) evolution at both the individual and …
Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5
ABSTRACT SERINC5 is a multi-pass transmembrane protein that is thought to play a role in
serine incorporation during cellular membrane biosynthesis. This protein has also been …
serine incorporation during cellular membrane biosynthesis. This protein has also been …