Early detection of viral pathogens by DNA-sensors in clinical samples, contaminated foods,
soil or water can dramatically improve clinical outcomes and reduce the socioeconomic …

Gene therapy has emerged as a promising therapeutic strategy for various conditions,
including blood disorders, ocular disease, cancer, and nervous system disorders. The …

Genetic robustness, or the ability of an organism to maintain fitness in the presence of
harmful mutations, can be achieved via protein feedback loops. Previous work has …

Cpf1 is a novel class of CRISPR-Cas DNA endonucleases, with a wide range of activity
across different eukaryotic systems. Yet, the underlying determinants of this variability are …

Upon fertilization, embryos undergo chromatin reprogramming and genome activation;
however, the mechanisms that regulate these processes are poorly understood. Here, we …

During the maternal-to-zygotic transition (MZT), multiple mechanisms precisely control
massive decay of maternal mRNAs. N 6-methyladenosine (m 6 A) is known to regulate …

The awakening of the genome after fertilization is a cornerstone of animal development.
However, the mechanisms that activate the silent genome after fertilization are poorly …

Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two
debilitating neurodevelopmental disorders. The former is associated with social impairments …

The recently discovered CRISPR-Cas gene editing system and its derivatives have found
numerous applications in fundamental biology research and pharmaceutical sciences. The …

The requirement for Cas nucleases to recognize a specific PAM is a major restriction for
genome editing. SpCas9 variants SpG and SpRY, recognizing NGN and NRN PAMs …