Transcription factor and microRNA co-regulatory loops: important regulatory motifs in biological processes and diseases
Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate target gene
expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs). These …
expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs). These …
AnimalTFDB 4.0: a comprehensive animal transcription factor database updated with variation and expression annotations
WK Shen, SY Chen, ZQ Gan, YZ Zhang… - Nucleic acids …, 2023 - academic.oup.com
Transcription factors (TFs) are proteins that interact with specific DNA sequences to regulate
gene expression and play crucial roles in all kinds of biological processes. To keep up with …
gene expression and play crucial roles in all kinds of biological processes. To keep up with …
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …
AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors
Abstract The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to
provide the most comprehensive and accurate information for animal transcription factors …
provide the most comprehensive and accurate information for animal transcription factors …
Decoding human fetal liver haematopoiesis
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …
A single-cell survey of the small intestinal epithelium
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and
help to coordinate immune responses. Here we report profiling of 53,193 individual …
help to coordinate immune responses. Here we report profiling of 53,193 individual …
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it
defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 …
defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 …
Fusion of regionally specified hPSC-derived organoids models human brain development and interneuron migration
Organoid techniques provide unique platforms to model brain development and
neurological disorders. Whereas several methods for recapitulating corticogenesis have …
neurological disorders. Whereas several methods for recapitulating corticogenesis have …
Multilineage communication regulates human liver bud development from pluripotency
Conventional two-dimensional differentiation from pluripotency fails to recapitulate cell
interactions occurring during organogenesis. Three-dimensional organoids generate …
interactions occurring during organogenesis. Three-dimensional organoids generate …
Transcriptome landscape of human folliculogenesis reveals oocyte and granulosa cell interactions
The dynamic transcriptional regulation and interactions of human germlines and
surrounding somatic cells during folliculogenesis remain unknown. Using RNA sequencing …
surrounding somatic cells during folliculogenesis remain unknown. Using RNA sequencing …