The road to generating transplantable organs: from blastocyst complementation to interspecies chimeras

C Zheng, EB Ballard, J Wu - Development, 2021 - journals.biologists.com
Growing human organs in animals sounds like something from the realm of science fiction,
but it may one day become a reality through a technique known as interspecies blastocyst …

[HTML][HTML] In vivo generation of organs by blastocyst complementation: advances and challenges

KM Founta, C Papanayotou - International Journal of Stem …, 2022 - synapse.koreamed.org
The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole
organs, in order to restore their proper function. Stem cell related technologies promise to …

Kidney ECM pregel nanoarchitectonics for microarrays to accelerate harvesting gene-edited porcine primary monoclonal spheres

M Gao, X Zhu, W Peng, Y He, Y Li, Q Wu, Y Zhou… - ACS …, 2022 - ACS Publications
One of the key steps of using CRISPR/Cas9 to obtain gene-edited cells used in generating
gene-edited animals combined with somatic cell nuclear transplantation (SCNT) is to …

[HTML][HTML] Towards human organ generation using interspecies blastocyst complementation: Challenges and perspectives for therapy

H Sarmah, A Sawada, Y Hwang, A Miura… - Frontiers in Cell and …, 2023 - frontiersin.org
Millions of people suffer from end-stage refractory diseases. The ideal treatment option for
terminally ill patients is organ transplantation. However, donor organs are in absolute …

[HTML][HTML] Derivation of transgene-free bat induced pluripotent stem cells amenable to chimera formation in mice, pigs, and chicks

Y Qin, C Li, X Gao, Y Wu, Z Guo, F Gao, D Yu, S Wu… - Cell Discovery, 2023 - nature.com
Dear Editor, The unique biological characteristics of bats, including longevity, antiviral
properties, hibernation, and echolocation, have garnered significant attention from the …

[HTML][HTML] Avian Embryonic Culture: A Perspective of In Ovo to Ex Ovo and In Vitro Studies

W Sukparangsi, A Thongphakdee… - Frontiers in Physiology, 2022 - frontiersin.org
The avian embryos growing outside the natural eggshell (ex ovo) were observed since the
early 19th century, and since then chick embryonic structures have revealed reaching an in …

Generation of functional xenogeneic germ and muscle stem cells via interspecies chimerism

J Zvick - 2023 - research-collection.ethz.ch
Pluripotent stem cells (PSCs), including embryonic and induced pluripotent stem cells
(ESCs and iPSCs) can contribute to all germ layers of the developing embryo when injected …

A Label-free Xenograft Model for Investigating the Behavior of Human Stem Cell Spheroids in Chick Embryos

IR Cordeiro, JM de Brito Neto - JoVE (Journal of Visualized Experiments), 2021 - jove.com
Xenografts are valuable methods to investigate the behavior of human cells in vivo. In
particular, the embryonic environment provides cues for cell migration, differentiation, and …

Action of neuroactive pharmaceuticals in neurodevelopmental models

D Zosen - 2022 - duo.uio.no
Nowadays, more people become predisposed to different brain-related illnesses, such as
epilepsy or depression. Many of the patients are women who might think about having a …

Avian Embryonic Culture: A Perspective of In Ovo to Ex Ovo and

S Yalcin, P Mozdziak, T Nomura - Avian incubation conditions …, 2023 - books.google.com
The avian embryos growing outside the natural eggshell (ex ovo) were observed since the
early 19th century, and since then chick embryonic structures have revealed reaching an in …