The prevalence of obesity is a major cause of many chronic metabolic disorders, including
type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and cancer. Insulin …

Overweight and obesity have become a world-wide problem. However, effective intervention
approaches are limited. Brown adipose tissue, which helps maintain body temperature and …

G protein-coupled receptors (GPCRs) are a large family of membrane protein receptors, and
Takeda G protein-coupled receptor 5 (TGR5) is a member of this family. As a membrane …

The G protein–coupled receptor 84 (GPR84), a medium-chain fatty acid receptor, has
garnered attention because of its potential involvement in a range of metabolic conditions …

Since metabolic process differs between humans and mice, studies were performed in
hamsters, which are generally considered to be a more appropriate animal model for studies …

Obesity, an excess accumulation of white adipose tissue (WAT), has become a global
epidemic and is associated with complex diseases, such as type 2 diabetes and …

Quercetin is the major representative of the flavonoid subgroup of flavones, with good
pharmacological activities for the treatment of liver diseases, including liver steatosis, fatty …

Brown and beige adipose tissues are the primary sites for adaptive non-shivering
thermogenesis. Although they have been known principally for their thermogenic effects, in …

Brown fats specialize in thermogenesis by increasing the utilization of circulating blood
glucose and fatty acids. Emerging evidence suggests that brown adipose tissue (BAT) …

Genetic gain-of-function mutations of warm temperature-sensitive transient receptor
potential vanilloid 3 (TRPV3) channel cause Olmsted syndrome characterized by severe …